Add to ORKGDespite adequate restoration of biochemical euthyroidism with replacement therapy with levothyroxine, a substantial amount of patients (~10-15%) with hypothyroidism display significant impairment of psychological well-being compared to controls of similar age and sex and show decrements in health status. The reasons for these observations are still unknown. The general focus of this thesis is therefore to explore the cause of persisting symptoms in treated hypothyroid patients and to find new biomarkers for thyroid state. Health-related QoL was impaired in 143 athyreotic patients with differentiated thyroid cancer on levothyroxine replacement therapy compared with a Dutch reference group. However, we did not find any association between...