The recognition of surgical care as an essential component of health care has required evidence of its potential impact in health care systems and cost-effectiveness by comparison with other standard interventions. Such evidence, essential for advocacy for resource allocation in LMICs, is very limited in children. Not only are there few outcomes and cost-effectiveness studies in the specialty, but the required disability weights for most common pediatric surgical conditions are missing, and multidisciplinary long-term follow-up is virtually non-existing, even in high-resource countries. The focus of this thesis is therefore two-fold. In part I the theoretical framework for surgical burden of disease measurement is reviewed and critiqued,...