A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts
- Middeldorp, C.M. (Christel)
- Hammerschlag, A.R. (Anke R.)
- Ouwens, K.G. (Klaasjan)
- Groen-Blokhuis, M. (Maria)
- St Pourcain, B. (Beate)
- Greven, C.U. (Corina U.)
- Pappa, M. (Magda)
- Tiesler, C.M.T. (Carla M.T.)
- Ang, W.Q. (Wei)
- Nolte, I.M. (Ilja)
- Vilor-Tejedor, N. (Natàlia)
- Bacelis, J. (Jonas)
- Ebejer, J.L. (Jane L.)
- Zhao, H. (Huiying)
- Davies, G.E. (Gareth)
- Ehli, E.A. (Erik)
- Evans, D.M. (David)
- Fedko, I.O. (Iryna O.)
- Guxens Junyent, M. (Mònica)
- Hottenga, J.J. (Jouke Jan)
- Hudziak, J.J. (James)
- Juqessur, A. (Astanand)
- Kemp, J.P. (John)
- Krapohl, E. (Eva)
- Martin, N.G. (Nicholas)
- Murcia, M. (Mario)
- Myhre, R. (Ronny)
- Ormel, J. (Johan)
- Ring, S.M. (Susan)
- Standl, E. (Eberhard)
- Stergiakouli, E. (Evangelia)
- Stoltenberg, C. (Camilla)
- Thiering, E. (Elisabeth)
- Timpson, N.J. (Nicholas)
- Trzaskowski, M. (Maciej)
- Most, P.J. (Peter) van der
- Wang, C.A. (Carol A.)
- Nyholt, D.R. (Dale)
- Medland, S.E. (Sarah)
- Neale, B.M. (Benjamin)
- Jacobsson, B. (Bo)
- Sunyer, J. (Jordi)
- Hartman, C.A. (C.)
- Whitehouse, A.J.O. (Andrew)
- Pennell, C.E. (Craig)
- Heinrich, J. (Joachim)
- Plomin, R. (Robert)
- Smith, A.V. (Davey)
- Tiemeier, H.W. (Henning)
- Posthuma, D. (Danielle)
- Boomsma, D.I. (Dorret)
DOIAbstract
Objective The aims of this study were to elucidate the influence of common genetic variants on childhood attention-deficit/hyperactivity disorder (ADHD) symptoms, to identify genetic variants that explain its high heritability, and to investigate the genetic overlap of ADHD symptom scores with ADHD diagnosis. Method Within the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, genome-wide single nucleotide polymorphisms (SNPs) and ADHD symptom scores were available for 17,666 children (<13 years of age) from nine population-based cohorts. SNP-based heritability was estimated in data from the three largest cohorts. Meta-analysis based on genome-wide association (GWA) analyses with SNPs was followed by gene-based association tests...
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