Associations of Maternal Vitamin B12 Concentration in Pregnancy with the Risks of Preterm Birth and Low Birth Weight: A Systematic Review and Meta-Analysis of Individual Participant Data
- Rogne, T. (Tormod)
- Tielemans, M.J. (Myrte)
- Chong, M.F.-F. (Mary Foong-Fong)
- Yajnik, C.S. (Chittaranjan S.)
- Krishnaveni, G.V. (Ghattu V.)
- Poston, L. (Lucilla)
- Jaddoe, V.W.V. (Vincent)
- Steegers, E.A.P. (Eric)
- Joshi, S. (Suyog)
- Chong, Y.-S. (Yap-Seng)
- Godfrey, N.
- Yap, F. (Fabian)
- Yahyaoui, R. (Raquel)
- Thomas, T. (Tinku)
- Hay, G. (Gry)
- Hogeveen, M. (Marije)
- Demir, A. (Ahmet)
- Saravanan, P. (Ponnusamy)
- Skovlund, E. (Eva)
- Martinussen, M.P. (Marit P.)
- Jacobsen, G.W. (Geir W.)
- Franco, O.H. (Oscar)
- Bracken, M.B. (Michael B.)
- Risnes, K.R. (Kari R.)
DOIAbstract
Vitamin B12 (hereafter referred to as B12) deficiency in pregnancy is prevalent and has been associated with both lower birth weight (birth weight <2,500 g) and preterm birth (length of gestation <37 weeks). Nevertheless, current evidence is contradictory. We performed a systematic review and a meta-analysis of individual participant data to evaluate the associations of maternal serum or plasma B12 concentrations in pregnancy with offspring birth weight and length of gestation. Twenty-two eligible studies were identified (11,993 observations). Eighteen studies were included in the meta-analysis (11,216 observations). No linear association was observed between maternal B12 levels in pregnancy and birth weight, but B12 deficiency (<148 pmol/L...
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