Supplementation with lactobacillus plantarum wcfs1 prevents decline of mucus barrier in colon of accelerated aging Ercc1-/Δ7 mice
- Beek, A.A. (Adriaan) van
- Sovran, B. (Bruno)
- Hugenholtz, F. (Floor)
- Meijer, B. (Ben)
- Hoogerland, J.A.
- Mihailova, V. (Violeta)
- van der Ploeg, C. (Corine)
- Belzer, C. (Clara)
- Boekschoten, M.V. (Mark V.)
- Hoeijmakers, J.H.J. (Jan)
- Vermeij, W.P. (Wilbert)
- De Vos, P. (Paul)
- Wells, J.M. (Jerry)
- Leenen, P.J.M. (Pieter)
- Nicoletti, C. (Claudio)
- Hendriks, R.W. (Rudi)
- Savelkoul, H.F.J. (Huub)
DOIAbstract
Although it is clear that probiotics improve intestinal barrier function, little is known about the effects of probiotics on the aging intestine. We investigated effects of 10-week bacterial supplementation of Lactobacillus plantarum WCFS1, Lactobacillus casei BL23, or Bifidobacterium breve DSM20213 on gut barrier and immunity in 16-week-old accelerated aging Ercc1-/Δ7 mice, which have a median lifespan of ~20 weeks, and their wild-type littermates. The colonic barrier in Ercc1-/Δ7 mice was characterized by a thin (< 10 μm) mucus layer. L. plantarum prevented this decline in mucus integrity in Ercc1-/Δ7 mice, whereas B. breve exacerbated it. Bacterial supplementations affected the expression of immune-related genes, inclu
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