Prognostic gene expression signatures have been proposed as clinical tools to clarify therapeutic options in acute myeloid leukemia (AML). However, these signatures rely on measuring large numbers of genes and often perform poorly when applied to independent cohorts or those with older patients. Long intergenic non-coding RNAs (lincRNAs) are emerging as important regulators of cell identity and oncogenesis, but knowledge of their utility as prognostic markers in AML is limited. Here we analyze transcriptomic data from multiple cohorts of clinically annotated AML patients and report that (i) microarrays designed for coding gene expression can be repurposed to yield robust lincRNA expression data, (ii) some lincRNA genes are located in close ...
BackgroundSome studies have proven that autophagy and lncRNA play important roles in AML. Several au...
Long non-coding RNAs (lncRNAs) are deregulated in several tumors, although their role in acute myelo...
Acute myeloid leukemia (AML) is a common hematological disorder with heterogeneous nature that resul...
© 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Prognostic gene e...
Background: Long non-coding RNA (lncRNA) expression has been implicated in a range of molecular mech...
PURPOSE: To identify a robust prognostic gene expression signature as an independent predictor of su...
Background: Acute Myeloid Leukemia (AML) is a complex and heterogeneous hematologic malignancy. Howe...
Background: Expression of long non-coding RNAs (lncRNAs) has recently been recognized as a potential...
Acute myeloid leukemia (AML) is the most frequently diagnosed type of acute leukemia in adults. It c...
Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides, located within the interg...
Background: Acute myeloid leukemia (AML) remains the most common type of hematopoietic malignancy in...
Patients with cytogenetically normal acute myeloid leukemia (CN-AML) show heterogeneous treatment ou...
Expression levels of long non-coding RNA (lncRNA) have been shown to associate with clinical outcom...
Journal Article;Long non-coding RNAs (lncRNAs) are deregulated in several tumors, although their rol...
2019 American Association for Cancer Research. We have previously shown that expression levels of 48...
BackgroundSome studies have proven that autophagy and lncRNA play important roles in AML. Several au...
Long non-coding RNAs (lncRNAs) are deregulated in several tumors, although their role in acute myelo...
Acute myeloid leukemia (AML) is a common hematological disorder with heterogeneous nature that resul...
© 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Prognostic gene e...
Background: Long non-coding RNA (lncRNA) expression has been implicated in a range of molecular mech...
PURPOSE: To identify a robust prognostic gene expression signature as an independent predictor of su...
Background: Acute Myeloid Leukemia (AML) is a complex and heterogeneous hematologic malignancy. Howe...
Background: Expression of long non-coding RNAs (lncRNAs) has recently been recognized as a potential...
Acute myeloid leukemia (AML) is the most frequently diagnosed type of acute leukemia in adults. It c...
Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides, located within the interg...
Background: Acute myeloid leukemia (AML) remains the most common type of hematopoietic malignancy in...
Patients with cytogenetically normal acute myeloid leukemia (CN-AML) show heterogeneous treatment ou...
Expression levels of long non-coding RNA (lncRNA) have been shown to associate with clinical outcom...
Journal Article;Long non-coding RNAs (lncRNAs) are deregulated in several tumors, although their rol...
2019 American Association for Cancer Research. We have previously shown that expression levels of 48...
BackgroundSome studies have proven that autophagy and lncRNA play important roles in AML. Several au...
Long non-coding RNAs (lncRNAs) are deregulated in several tumors, although their role in acute myelo...
Acute myeloid leukemia (AML) is a common hematological disorder with heterogeneous nature that resul...