The actin cytoskeleton regulates LFA-ligand binding through avidity rather than affinity changes.

A small-molecule antagonist of LFA-1 blocks a conformational change important for LFA-1 function

Joseph R. Woska
Daw-tsun Shih
Viviany R. Taqueti
Nancy Hogg
Terence A. Kelly
Takashi K. Kishimoto

June 2015

Abstract: Lymphocyte function-associated antigen (LFA)-1/intercellular adhesion molecule (ICAM)-1 in...

A single amino acid in the cytoplasmic domain of the beta 2 integrin lymphocyte function-associated antigen-1 regulates avidity-dependent inside-out signaling.

Bleijs, D.A.
Duijnhoven, G.C.F. van
Vliet, S.J. van
Thijssen, J.P.H.
Figdor, C.G.
Kooyk, Y. van

January 2001

Contains fulltext : 142518.pdf (Publisher’s version ) (Open Access)The leukocyte-s...

Role of the actin cytoskeleton in regulating LYVE-1 lateral diffusion and function

Stanly, T

January 2017

The lymphatic endothelial receptor LYVE-1 investigated here is a weak binder to its ligand hyalurona...

Role of the cytoplasmic domain and cytoskeleton in regulating LFA-1 mediated adhesion

Lub, M.

January 1996

Contains fulltext : mmubn000001_234353473.pdf (publisher's version ) (Open Access)...

Making a little affinity go a long way: a topological view of LFA-1 regulation.

Dustin, ML

January 1998

Lymphocytes utilize adhesion to navigate in the body and to transiently interact with a variety of p...

Dual role of the actin cytoskeleton in regulating cell adhesion mediated by the integrin lymphocyte function-associated molecule-1

Lub, M
van Kooyk, Y
van Vliet, S J
Figdor, C G

February 1997

Intracellular signals are required to activate the leukocyte-specific adhesion receptor lymphocyte f...

Cytoskeletal Regulation Couples LFA-1 Conformational Changes to Receptor Lateral Mobility and Clustering

Cairo, Christopher W.
Mirchev, Rossen
Golan, David E.

August 2006

SummaryThe αLβ2 integrin (leukocyte function-associated antigen-1 [LFA-1]) is regulated to engage an...

Cytoskeletal restraints regulate homotypic ALCAM-mediated adhesion through PKCalpha independently of Rho-like GTPases.

Zimmerman, A.W.
Nelissen, J.M.
Emst-de Vries, S.E. van
Willems, P.H.G.M.
Lange, F. de
Collard, J.G.
Leeuwen, F.N. van
Figdor, C.G.

January 2004

Contains fulltext : 57147.pdf (publisher's version ) (Open Access)The activated le...

Organization of the integrin LFA-1 in nanoclusters regulates its activity.

Cambi, A.
Joosten, B.H.G.M.
Koopman, M.
Lange, F. de
Beeren, I.M.J.
Torensma, R.
Fransen, J.A.M.
Garcia-Parajo, M.F.
Leeuwen, F.N. van
Figdor, C.G.

January 2006

Contains fulltext : 51243.pdf (publisher's version ) (Open Access)The beta2-integr...

Cytoplasmic tails of beta1, beta2, and beta7 integrins differentially regulate LFA-1 function in K562 cells

Lub, M.
Vliet, S.J. van
Oomen, S.P.M.A.
Pieters, R.A.
Robinson, M.K.
Figdor, C.G.
Kooyk, Y. van

January 1997

Contains fulltext : 27105___.PDF (publisher's version ) (Open Access

Role of LFA-1/ICAM adhesion in leukocyte/stromal cell interaction

Kooyk, Y. van
Binnerts, M.E.
Figdor, C.G.

January 1996

Contains fulltext : 27128___.PDF (publisher's version ) (Open Access

Distinct kinetic and mechanical properties govern ALCAM-mediated interactions as shown by single-molecule force spectroscopy.

Riet, J. te
Zimmerman, A.W.
Cambi, A.
Joosten, B.H.G.M.
Speller, Sylvia
Torensma, R.
Leeuwen, F.N. van
Figdor, C.G.
Lange, F. de

January 2007

Contains fulltext : 34842.pdf (publisher's version ) (Open Access)The activated le...

Regulation of LFA-1-mediated T cell adhesion by CD4

Mazerolles, F.
Hauss, P.
Barbat, C.
Figdor, C.G.
Fischer, A.

January 1991

Contains fulltext : 27189___.PDF (publisher's version ) (Open Access

LFA-1 outside-in signalling and actin cytoskeleton reorganization in cytotoxic T lymphocytes

MacLeod, Matthew Alexander

January 2006

Integrins are heterodimeric cell-surface receptors that mediate the adhesion of cells to the extrac...

Actin-targeting natural compounds as tools to study the role of actin cytoskeleton in signal transduction.

Kustermans, Gaëlle
Piette, Jacques
Legrand, Sylvie

December 2008

Actin cytoskeleton controls a vast range of cellular processes such as motility, cytokinesis, diffe...

A small-molecule antagonist of LFA-1 blocks a conformational change important for LFA-1 function

Joseph R. Woska
Daw-tsun Shih
Viviany R. Taqueti
Nancy Hogg
Terence A. Kelly
Takashi K. Kishimoto

June 2015

Abstract: Lymphocyte function-associated antigen (LFA)-1/intercellular adhesion molecule (ICAM)-1 in...

A single amino acid in the cytoplasmic domain of the beta 2 integrin lymphocyte function-associated antigen-1 regulates avidity-dependent inside-out signaling.

Bleijs, D.A.
Duijnhoven, G.C.F. van
Vliet, S.J. van
Thijssen, J.P.H.
Figdor, C.G.
Kooyk, Y. van

January 2001

Contains fulltext : 142518.pdf (Publisher’s version ) (Open Access)The leukocyte-s...

Role of the actin cytoskeleton in regulating LYVE-1 lateral diffusion and function

Stanly, T

January 2017

The lymphatic endothelial receptor LYVE-1 investigated here is a weak binder to its ligand hyalurona...

Role of the cytoplasmic domain and cytoskeleton in regulating LFA-1 mediated adhesion

Lub, M.

January 1996

Contains fulltext : mmubn000001_234353473.pdf (publisher's version ) (Open Access)...

Making a little affinity go a long way: a topological view of LFA-1 regulation.

Dustin, ML

January 1998

Lymphocytes utilize adhesion to navigate in the body and to transiently interact with a variety of p...

Dual role of the actin cytoskeleton in regulating cell adhesion mediated by the integrin lymphocyte function-associated molecule-1

Lub, M
van Kooyk, Y
van Vliet, S J
Figdor, C G

February 1997

Intracellular signals are required to activate the leukocyte-specific adhesion receptor lymphocyte f...

Cytoskeletal Regulation Couples LFA-1 Conformational Changes to Receptor Lateral Mobility and Clustering

Cairo, Christopher W.
Mirchev, Rossen
Golan, David E.

August 2006

SummaryThe αLβ2 integrin (leukocyte function-associated antigen-1 [LFA-1]) is regulated to engage an...

Cytoskeletal restraints regulate homotypic ALCAM-mediated adhesion through PKCalpha independently of Rho-like GTPases.

Zimmerman, A.W.
Nelissen, J.M.
Emst-de Vries, S.E. van
Willems, P.H.G.M.
Lange, F. de
Collard, J.G.
Leeuwen, F.N. van
Figdor, C.G.

January 2004

Contains fulltext : 57147.pdf (publisher's version ) (Open Access)The activated le...

Organization of the integrin LFA-1 in nanoclusters regulates its activity.

Cambi, A.
Joosten, B.H.G.M.
Koopman, M.
Lange, F. de
Beeren, I.M.J.
Torensma, R.
Fransen, J.A.M.
Garcia-Parajo, M.F.
Leeuwen, F.N. van
Figdor, C.G.

January 2006

Contains fulltext : 51243.pdf (publisher's version ) (Open Access)The beta2-integr...

Cytoplasmic tails of beta1, beta2, and beta7 integrins differentially regulate LFA-1 function in K562 cells

Lub, M.
Vliet, S.J. van
Oomen, S.P.M.A.
Pieters, R.A.
Robinson, M.K.
Figdor, C.G.
Kooyk, Y. van

January 1997

Contains fulltext : 27105___.PDF (publisher's version ) (Open Access

Role of LFA-1/ICAM adhesion in leukocyte/stromal cell interaction

Kooyk, Y. van
Binnerts, M.E.
Figdor, C.G.

January 1996

Contains fulltext : 27128___.PDF (publisher's version ) (Open Access

Distinct kinetic and mechanical properties govern ALCAM-mediated interactions as shown by single-molecule force spectroscopy.

Riet, J. te
Zimmerman, A.W.
Cambi, A.
Joosten, B.H.G.M.
Speller, Sylvia
Torensma, R.
Leeuwen, F.N. van
Figdor, C.G.
Lange, F. de

January 2007

Contains fulltext : 34842.pdf (publisher's version ) (Open Access)The activated le...

Regulation of LFA-1-mediated T cell adhesion by CD4

Mazerolles, F.
Hauss, P.
Barbat, C.
Figdor, C.G.
Fischer, A.

January 1991

Contains fulltext : 27189___.PDF (publisher's version ) (Open Access

LFA-1 outside-in signalling and actin cytoskeleton reorganization in cytotoxic T lymphocytes

MacLeod, Matthew Alexander

January 2006

Integrins are heterodimeric cell-surface receptors that mediate the adhesion of cells to the extrac...

Actin-targeting natural compounds as tools to study the role of actin cytoskeleton in signal transduction.

Kustermans, Gaëlle
Piette, Jacques
Legrand, Sylvie

December 2008

Actin cytoskeleton controls a vast range of cellular processes such as motility, cytokinesis, diffe...

A small-molecule antagonist of LFA-1 blocks a conformational change important for LFA-1 function

Joseph R. Woska
Daw-tsun Shih
Viviany R. Taqueti
Nancy Hogg
Terence A. Kelly
Takashi K. Kishimoto

June 2015

Abstract: Lymphocyte function-associated antigen (LFA)-1/intercellular adhesion molecule (ICAM)-1 in...

A single amino acid in the cytoplasmic domain of the beta 2 integrin lymphocyte function-associated antigen-1 regulates avidity-dependent inside-out signaling.

Bleijs, D.A.
Duijnhoven, G.C.F. van
Vliet, S.J. van
Thijssen, J.P.H.
Figdor, C.G.
Kooyk, Y. van

January 2001

Contains fulltext : 142518.pdf (Publisher’s version ) (Open Access)The leukocyte-s...

Role of the actin cytoskeleton in regulating LYVE-1 lateral diffusion and function

Stanly, T

January 2017

The lymphatic endothelial receptor LYVE-1 investigated here is a weak binder to its ligand hyalurona...

The actin cytoskeleton regulates LFA-ligand binding through avidity rather than affinity changes.

Abstract

Extracted data

The actin cytoskeleton regulates LFA-ligand binding through avidity rather than affinity changes.

Abstract

Extracted data

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