BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9(+) leukemic cells

Inhibition of the phosphatidylinositol-3-kinase pathway is selectively cytotoxic to primitive and mature acute myeloid leukemia progenitor cells while sparing their normal counterparts

Muranyi, Andrew L.

May 2010

Acute myeloid leukemia (AML) is a disorder of the hematopoietic system in which there is an overprod...

FMS-like Tyrosine Kinase 3/FLT3 : From Basic Science to Clinical Implications

Kazi, Julhash U.
Rönnstrand, Lars

January 2019

FMS-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that is expressed almost exclusively...

Clinical use of FLT3 inhibitors in acute myeloid leukemia

Sutamtewagul G
Vigil CE

October 2018

Grerk Sutamtewagu, Carlos E Vigil Division of Hematology, Oncology and Blood and Marrow Transplanta...

BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells

Carretta, Marco
Brouwers-Vos, Annet Z.
Bosman, Matthieu
Horton, Sarah J.
Martens, Joost H. A.
Vellenga, Edo
Schuringa, Jan Jacob

December 2017

In the present work we aimed to identify targetable signaling networks in human MLL-AF9 leukemias. W...

BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells.

Marco Carretta
Annet Z Brouwers-Vos
Matthieu Bosman
Sarah J Horton
Joost H A Martens
Edo Vellenga
Jan Jacob Schuringa

January 2017

In the present work we aimed to identify targetable signaling networks in human MLL-AF9 leukemias. W...

BRD9 binds cell type-specific chromatin regions regulating leukemic cell survival via STAT5 inhibition

Gaudio, Nunzio Del
Costanzo, Antonella Di
Liu, Ning Qing
Conte, Lidio
Migliaccio, Antimo
Vermeulen, Michiel
Martens, J.H.A.
Stunnenberg, H.G.
Altucci, Lucia

January 2019

Contains fulltext : 203979.pdf (publisher's version ) (Open Access)14 p

Inhibition of FLT3 in MLL Validation of a therapeutic target identified by gene expression based classification

Armstrong, Scott A
Kung, Andrew L
Mabon, Meghann E
Silverman, Lewis B
Stam, Ronald W
Den Boer, Monique L
Pieters, Rob
Kersey, John H
Sallan, Stephen E
Fletcher, Jonathan A
Golub, Todd R
Griffin, James D
Korsmeyer, Stanley J

February 2003

AbstractWe recently found that MLL-rearranged acute lymphoblastic leukemias (MLL) have a unique gene...

The Myc/Max/Mxd Network Is a Target of Mutated Flt3 Signaling in Hematopoietic Stem Cells in Flt3-ITD-Induced Myeloproliferative Disease

Basit, F.
Andersson, M.
Hultquist, A.

January 2018

Contains fulltext : 200443.pdf (publisher's version ) (Open Access)Acute myeloid l...

BRD9 degraders as chemosensitizers in acute leukemia and multiple myeloma.

Weisberg, Ellen
Chowdhury, Basudev
Meng, Chengcheng
Case, Abigail
Ni, Wei
Garg, Swati
Sattler, Martin
Azab, Abdel Kareem
Sun, Jennifer
Muz, Barbara
Sanchez, Dana
Toure, Anthia
Stone, Richard
Galinsky, Ilene
Winer, Eric
Gleim, Scott
Gkountela, Sofia
Kedves, Alexia
Harrington, Edmund
Abrams, Tinya
Zoller, Thomas
Vaupel, Andrea
Manley, Paul
Faller, Michael
Chung, BoYee
Chen, Xin
Busenhart, Philipp
Stephan, Christine
Calkins, Keith
Bonenfant, Debora
Thoma, Claudio
Forrester, William
Griffin, James

July 2022

Bromodomain-containing protein 9 (BRD9), an essential component of the SWI/SNF chromatin remodeling ...

Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition

Hohmann, A. F.
Martin, L. J.
Minder, J. L.
Roe, J. S.
Shi, J.
Steurer, S.
Bader, G.
McConnell, D.
Pearson, M.
Gerstberger, T.
Gottschamel, T.
Thompson, D.
Suzuki, Y.
Koegl, M.
Vakoc, C. R.

September 2016

Here we show that acute myeloid leukemia (AML) cells require the BRD9 subunit of the SWI-SNF chromat...

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia AML

Herrmann, H.
Blatt, K.
Shi, J.
Gleixner, K. V.
Cerny-Reiterer, S.
Mullauer, L.
Vakoc, C. R.
Sperr, W. R.
Horny, H. P.
Bradner, J. E.
Zuber, J.
Valent, P.

December 2012

Acute myeloid leukemia (AML) is a life-threatening stem cell disease characterized by uncontrolled p...

Functional interdependence of BRD4 and DOT1L in MLL leukemia.

Gilan, O
Lam, EYN
Becher, I
Lugo, D
Cannizzaro, E
Joberty, G
Ward, A
Wiese, M
Fong, CY
Ftouni, S
Tyler, D
Stanley, K
MacPherson, L
Weng, C-F
Chan, Y-C
Ghisi, M
Smil, D
Carpenter, C
Brown, P
Garton, N
Blewitt, ME
Bannister, Andrew
Kouzarides, Tony
Huntly, Brian
Johnstone, RW
Drewes, G
Dawson, S-J
Arrowsmith, CH
Grandi, P
Prinjha, RK
Dawson, MA

July 2016

Targeted therapies against disruptor of telomeric silencing 1-like (DOT1L) and bromodomain-containin...

Overcoming the Protective Effect of the Bone Marrow Microenvironment by Dual FLT3 and BET Inhibition in FLT3-ITD Acute Myeloid Leukemia

Lee, Lauren

July 2019

Acute myeloid leukemia (AML) develops from a block in the terminal differentiation of myeloid progen...

Flt3 Does Not Play a Critical Role in Murine Myeloid Leukemias Induced by MLL Fusion Genes

Ester Morgado

January 2013

Leukemias harboring MLL translocations are frequent in children and adults, and respond poorly to th...

BRD9 degraders as chemosensitizers in acute leukemia and multiple myeloma

Ellen Weisberg
Basudev Chowdhury
Chengcheng Meng
Abigail E. Case
Wei Ni
Swati Garg
Martin Sattler
Abdel Kareem Azab
Jennifer Sun
Barbara Muz
Dana Sanchez
Anthia Toure
Richard M. Stone
Ilene Galinsky
Eric Winer
Scott Gleim
Sofia Gkountela
Alexia Kedves
Edmund Harrington
Tinya Abrams
Thomas Zoller
Andrea Vaupel
Paul Manley
Michael Faller
BoYee Chung
Xin Chen
Philipp Busenhart
Christine Stephan
Keith Calkins
Debora Bonenfant
Claudio R. Thoma
William Forrester
James D. Griffin

July 2022

Abstract Bromodomain-containing protein 9 (BRD9), an essential component of the SWI/SNF chromatin re...

Inhibition of the phosphatidylinositol-3-kinase pathway is selectively cytotoxic to primitive and mature acute myeloid leukemia progenitor cells while sparing their normal counterparts

Muranyi, Andrew L.

May 2010

Acute myeloid leukemia (AML) is a disorder of the hematopoietic system in which there is an overprod...

FMS-like Tyrosine Kinase 3/FLT3 : From Basic Science to Clinical Implications

Kazi, Julhash U.
Rönnstrand, Lars

January 2019

FMS-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that is expressed almost exclusively...

Clinical use of FLT3 inhibitors in acute myeloid leukemia

Sutamtewagul G
Vigil CE

October 2018

Grerk Sutamtewagu, Carlos E Vigil Division of Hematology, Oncology and Blood and Marrow Transplanta...

BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells

Carretta, Marco
Brouwers-Vos, Annet Z.
Bosman, Matthieu
Horton, Sarah J.
Martens, Joost H. A.
Vellenga, Edo
Schuringa, Jan Jacob

December 2017

In the present work we aimed to identify targetable signaling networks in human MLL-AF9 leukemias. W...

BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells.

Marco Carretta
Annet Z Brouwers-Vos
Matthieu Bosman
Sarah J Horton
Joost H A Martens
Edo Vellenga
Jan Jacob Schuringa

January 2017

In the present work we aimed to identify targetable signaling networks in human MLL-AF9 leukemias. W...

BRD9 binds cell type-specific chromatin regions regulating leukemic cell survival via STAT5 inhibition

Gaudio, Nunzio Del
Costanzo, Antonella Di
Liu, Ning Qing
Conte, Lidio
Migliaccio, Antimo
Vermeulen, Michiel
Martens, J.H.A.
Stunnenberg, H.G.
Altucci, Lucia

January 2019

Contains fulltext : 203979.pdf (publisher's version ) (Open Access)14 p

Inhibition of FLT3 in MLL Validation of a therapeutic target identified by gene expression based classification

Armstrong, Scott A
Kung, Andrew L
Mabon, Meghann E
Silverman, Lewis B
Stam, Ronald W
Den Boer, Monique L
Pieters, Rob
Kersey, John H
Sallan, Stephen E
Fletcher, Jonathan A
Golub, Todd R
Griffin, James D
Korsmeyer, Stanley J

February 2003

AbstractWe recently found that MLL-rearranged acute lymphoblastic leukemias (MLL) have a unique gene...

The Myc/Max/Mxd Network Is a Target of Mutated Flt3 Signaling in Hematopoietic Stem Cells in Flt3-ITD-Induced Myeloproliferative Disease

Basit, F.
Andersson, M.
Hultquist, A.

January 2018

Contains fulltext : 200443.pdf (publisher's version ) (Open Access)Acute myeloid l...

BRD9 degraders as chemosensitizers in acute leukemia and multiple myeloma.

Weisberg, Ellen
Chowdhury, Basudev
Meng, Chengcheng
Case, Abigail
Ni, Wei
Garg, Swati
Sattler, Martin
Azab, Abdel Kareem
Sun, Jennifer
Muz, Barbara
Sanchez, Dana
Toure, Anthia
Stone, Richard
Galinsky, Ilene
Winer, Eric
Gleim, Scott
Gkountela, Sofia
Kedves, Alexia
Harrington, Edmund
Abrams, Tinya
Zoller, Thomas
Vaupel, Andrea
Manley, Paul
Faller, Michael
Chung, BoYee
Chen, Xin
Busenhart, Philipp
Stephan, Christine
Calkins, Keith
Bonenfant, Debora
Thoma, Claudio
Forrester, William
Griffin, James

July 2022

Bromodomain-containing protein 9 (BRD9), an essential component of the SWI/SNF chromatin remodeling ...

Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition

Hohmann, A. F.
Martin, L. J.
Minder, J. L.
Roe, J. S.
Shi, J.
Steurer, S.
Bader, G.
McConnell, D.
Pearson, M.
Gerstberger, T.
Gottschamel, T.
Thompson, D.
Suzuki, Y.
Koegl, M.
Vakoc, C. R.

September 2016

Here we show that acute myeloid leukemia (AML) cells require the BRD9 subunit of the SWI-SNF chromat...

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia AML

Herrmann, H.
Blatt, K.
Shi, J.
Gleixner, K. V.
Cerny-Reiterer, S.
Mullauer, L.
Vakoc, C. R.
Sperr, W. R.
Horny, H. P.
Bradner, J. E.
Zuber, J.
Valent, P.

December 2012

Acute myeloid leukemia (AML) is a life-threatening stem cell disease characterized by uncontrolled p...

Functional interdependence of BRD4 and DOT1L in MLL leukemia.

Gilan, O
Lam, EYN
Becher, I
Lugo, D
Cannizzaro, E
Joberty, G
Ward, A
Wiese, M
Fong, CY
Ftouni, S
Tyler, D
Stanley, K
MacPherson, L
Weng, C-F
Chan, Y-C
Ghisi, M
Smil, D
Carpenter, C
Brown, P
Garton, N
Blewitt, ME
Bannister, Andrew
Kouzarides, Tony
Huntly, Brian
Johnstone, RW
Drewes, G
Dawson, S-J
Arrowsmith, CH
Grandi, P
Prinjha, RK
Dawson, MA

July 2016

Targeted therapies against disruptor of telomeric silencing 1-like (DOT1L) and bromodomain-containin...

Overcoming the Protective Effect of the Bone Marrow Microenvironment by Dual FLT3 and BET Inhibition in FLT3-ITD Acute Myeloid Leukemia

Lee, Lauren

July 2019

Acute myeloid leukemia (AML) develops from a block in the terminal differentiation of myeloid progen...

Flt3 Does Not Play a Critical Role in Murine Myeloid Leukemias Induced by MLL Fusion Genes

Ester Morgado

January 2013

Leukemias harboring MLL translocations are frequent in children and adults, and respond poorly to th...

BRD9 degraders as chemosensitizers in acute leukemia and multiple myeloma

Ellen Weisberg
Basudev Chowdhury
Chengcheng Meng
Abigail E. Case
Wei Ni
Swati Garg
Martin Sattler
Abdel Kareem Azab
Jennifer Sun
Barbara Muz
Dana Sanchez
Anthia Toure
Richard M. Stone
Ilene Galinsky
Eric Winer
Scott Gleim
Sofia Gkountela
Alexia Kedves
Edmund Harrington
Tinya Abrams
Thomas Zoller
Andrea Vaupel
Paul Manley
Michael Faller
BoYee Chung
Xin Chen
Philipp Busenhart
Christine Stephan
Keith Calkins
Debora Bonenfant
Claudio R. Thoma
William Forrester
James D. Griffin

July 2022

Abstract Bromodomain-containing protein 9 (BRD9), an essential component of the SWI/SNF chromatin re...

Inhibition of the phosphatidylinositol-3-kinase pathway is selectively cytotoxic to primitive and mature acute myeloid leukemia progenitor cells while sparing their normal counterparts

Muranyi, Andrew L.

May 2010

Acute myeloid leukemia (AML) is a disorder of the hematopoietic system in which there is an overprod...

FMS-like Tyrosine Kinase 3/FLT3 : From Basic Science to Clinical Implications

Kazi, Julhash U.
Rönnstrand, Lars

January 2019

FMS-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that is expressed almost exclusively...

Clinical use of FLT3 inhibitors in acute myeloid leukemia

Sutamtewagul G
Vigil CE

October 2018

Grerk Sutamtewagu, Carlos E Vigil Division of Hematology, Oncology and Blood and Marrow Transplanta...

BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9(+) leukemic cells

Abstract

Extracted data

BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9(+) leukemic cells

Abstract

Extracted data

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