The identification undesired or abnormal states of a nuclear power plant is of primary importance for defining accident prevention and mitigation actions. To this aim, computational models and simulators are frequently employed, as they allow to study the system response to different operational conditions. For complex systems like the nuclear power plants, this is in general challenging because the simulation tools are i) high-dimensional; ii) black-box; iii) dynamic and iv) computationally demanding. In this paper, an adaptive simulation framework recently proposed by some of the authors is tailored for the analysis of accident scenarios involving the control system of the Advanced Lead-cooled Fast Reactor European Demonstrator (ALFRED). ...