Quercetin prevents liver carcinogenesis by inducing cell cycle arrest, decreasing cell proliferation and enhancing apoptosis
- Casella, María Laura
- Parody, Juan Pablo
- Ceballos, María Paula
- Quiroga, Ariel Darío
- Ronco, María Teresa
- Francés, Daniel Eleazar
- Monti, Juan Alberto
- Pisani, Gerardo Bruno
- Carnovale, Cristina Ester
- Carrillo, María Cristina
- Álvarez, María de Luján
DOIAbstract
Quercetin is the most abundant flavonoid in human diet. It has special interest since it holds anticancerous properties. This study aims to clarify the mechanisms involved in quercetin effects during the occurrence of preneoplastic lesions in rat liver. Adult male Wistar rats were subjected to a two-phase model of hepatocarcinogenesis (IP group). IP animals also received quercetin 10 and 20 mg/kg body weight (IPQ10 and IPQ20 groups, respectively). Antioxidant defenses were modified by quercetin administration at both doses. However, only IPQ20 group showed a reduction in number and volume of preneoplastic lesions. This group showed increased apoptosis and a reduction in the proliferative index. In addition, IPQ20 group displayed a reductio...
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