New genetic loci link adipose and insulin biology to body fat distribution
- Shungin, D
- Winkler, TW
- Croteau-Chonka, DC
- Ferreira, T
- Locke, AE
- Mägi, R
- Strawbridge, RJ
- Pers, TH
- Fischer, K
- Justice, AE
- Workalemahu, T
- Wu, JMW
- Buchkovich, ML
- Heard-Costa, NL
- Roman, TS
- Drong, AW
- Song, C
- Gustafsson, S
- Day, FR
- Esko, T
- Fall, T
- Kutalik, Z
- Luan, J
- Randall, JC
- Scherag, A
- Vedantam, S
- Wood, AR
- Chen, J
- Fehrmann, R
- Karjalainen, J
- Kahali, B
- Liu, CT
- Schmidt, EM
- Absher, D
- Amin, N
- Anderson, D
- Beekman, M
- Bragg-Gresham, JL
- Buyske, S
- Demirkan, A
- Ehret, GB
- Feitosa, MF
- Goel, A
- Jackson, AU
- Johnson, T
- Kleber, ME
- Kristiansson, K
- Mangino, M
- Leach, IM
- Medina-Gomez, C
- Palmer, CD
- Pasko, D
- Pechlivanis, S
- Peters, MJ
- Prokopenko, I
- Stančáková, A
- Sung, YJ
- Tanaka, T
- Teumer, A
- Van Vliet-Ostaptchouk, JV
- Yengo, L
- Zhang, W
- Albrecht, E
- Ärnlöv, J
- Arscott, GM
- Bandinelli, S
- Barrett, A
- Bellis, C
- Bennett, AJ
- Berne, C
- Blüher, M
- Böhringer, S
- Bonnet, F
- Böttcher, Y
- Bruinenberg, M
- Carba, DB
- Caspersen, IH
- Clarke, R
- Daw, EW
- Deelen, J
- Deelman, E
- Delgado, G
- Doney, AS
- Eklund, N
- Erdos, MR
- Estrada, K
- Eury, E
- Friedrich, N
- Garcia, ME
- Giedraitis, V
- Gigante, B
- Go, AS
- Golay, A
- Grallert, H
- Grammer, TB
- Gräßler, J
- Grewal, J
- Groves, CJ
- Haller, T
- Hallmans, G
DOIAbstract
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, we conducted genome-wide association meta-analyses of waist and hip circumference-related traits in up to 224,459 individuals. We identified 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (WHRadjBMI) and an additional 19 loci newly associated with related waist and hip circumference measures (P<5×10-8). Twenty of the 49 WHRadjBMI loci showed significant sexual dimorphism, 19 of which displayed a stronger effect in women. The identified loci wer...
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