HCV reinfection incidence among individuals treated for recent infection
- Martinello, M
- Grebely, J
- Petoumenos, K
- Gane, E
- Hellard, M
- Shaw, D
- Sasadeusz, J
- Applegate, TL
- Dore, GJ
- Matthews, GV
DOIAbstract
One challenge to HCV elimination through therapeutic intervention is reinfection. The aim of this analysis was to calculate the incidence of HCV reinfection among both HIV-positive and HIV-negative individuals treated for recent HCV infection (estimated infection duration <18 months). Individuals with recent HCV infection who achieved an end-of-treatment response in four open-label studies between 2004 and 2015 in Australia and New Zealand were assessed for HCV reinfection, confirmed by sequencing of the Core-E2 and/or NS5B regions. Reinfection incidence was calculated using person-time of observation. Exact Poisson regression analysis was used to assess factors associated with HCV reinfection. The cohort at risk for reinfection (n=120; 83%...
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