Chronic hepatitis C infection and liver disease in HIV-coinfected patients in Asia
- Durier, N
- Yunihastuti, E
- Ruxrungtham, K
- Kinh, NV
- Kamarulzaman, A
- Boettiger, D
- Widhani, A
- Avihingsanon, A
- Huy, BV
- Syed Omar, SFB
- Sanityoso, A
- Chittmittrapap, S
- Dung, NTH
- Pillai, V
- Suwan-Ampai, T
- Law, M
- Sohn, AH
- Matthews, G
DOIAbstract
Data on markers of hepatitis C virus (HCV) disease in HIV-HCV-coinfected patients in resource-limited settings are scarce. We assessed HCV RNA, HCV genotype (GT), IL28B GT and liver fibrosis (FibroScan®) in 480 HIV-infected patients with positive HCV antibody in four HIV treatment centres in South-East Asia. We enrolled 165 (34.4%) patients in Jakarta, 158 (32.9%) in Bangkok, 110 (22.9%) in Hanoi and 47 (9.8%) in Kuala Lumpur. Overall, 426 (88.8%) were male, the median (IQR) age was 38.1 (34.7-42.5) years, 365 (76.0%) reported HCV exposure through injecting drug use, and 453 (94.4%) were on combination antiretroviral therapy. The median (IQR) CD4 count was 446 (325-614) cells/mm3 and 208 (94.1%) of 221 patients tested had HIV-1 RNA <400 cop...
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