This thesis contributes to the current debates concerning the optimal strength of Intellectual Property Rights (IPR) protection and the importance of such a system. The first part of the thesis constructs game theoretic models to examine the relationship between the strength of IPR and market size and how this relationship changes in the presence of licensing. The second part investigates empirically the effect of knowledge tradeability proxied by licensing activity on the choice of IPR protection strategies at the firm level.A particular issue of interest is how an increase in market size affects the strength of IPR protection. Chapter 2 addresses this question in a simple oligopoly model of R&D and Cournot competition with endogenous IPR ...