MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer
- Hitchins, Megan, Clinical School - St Vincent's Hospital, Faculty of Medicine, UNSW
- Williams, R
- Cheong, K
- Halani, N
- Lin, V
- Packham, D
- Ku, S
- Buckle, Andrew, Medical Sciences, Faculty of Medicine, UNSW
- Hawkins, Nicholas, Medical Sciences, Faculty of Medicine, UNSW
- Burn, J
DOIAbstract
BACKGROUND & AIMS: Hereditary nonpolyposis colorectal cancer (HNPCC) is caused by heterozygous germline sequence mutations of DNA mismatch repair genes, most frequently MLH1 or MSH2. A novel molecular mechanism for HNPCC has recently been suggested by th
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