CD4 cell-monitored treatment interruption in patients with a CD4 cell count > 500 X 10(6) cells/I

Mussini, C
Bedini, A
Borghi, V
Guaraldi, G
Esposito, R
Barchi, E
COZZI-LEPRI, A
Philips, An
Ortolani, P
Bratt, G
Eriksson, Le
Sighinolfi, L
Cossarizza, A
D'ARMINIO MONFORTE, A
DE LUCA, A
DI GIAMBENEDETTO, S
Antinori, A

Publication date

January 2005

Abstract

Background: Little is known about CD4 cell count changes in patients with high CD4 cell counts who interrupt antiretroviral therapy, especially in those with a nadir of 250-350 × 106 cells/l. Methods: Data derived from 139 patients from seven prospective cohorts who had > 12 months highly active antiretroviral therapy (HAART), CD4 cell count nadir of > 250 × 106 cells/l and at pre-interruption of > 500 × 106 cells/l. Endpoint was time to CD4 cell count 350 × 106 cells/l for a substantial period of time