Tibiofemoral lateral compartment’s morphology as a risk factor: a radiographic comparison between ACL-ruptured and non-injured subjects

Background Tibiofemoral bone morphology has been proposed as a potential risk factor for anterior cruciate ligament (ACL) rupture, with recent increasing interest in the lateral femoral condyle. Objective Investigate several tibiofemoral bone morphology measurements as risk factors for rupturing the ACL. Design Retrospective case–control study. Setting Clinical setting. Patients (or Participants) 200 ACL-ruptured patients and 200 normal subjects without history of previous knee injuries, with a mean age of 24 years old. Main Outcome Measurements Presence or not of ACL rupture. Assessment of Risk Factors Radiographic measurements of the distal epiphysis/diaphysis of the femur and proximal epiphysis of the tibia were performed, including: anteroposterior-flattened surface of the femur's lateral condyle; femur's diaphysis anteroposterior distance; anteroposterior distance of the femur's lateral condyle; height of the femur's lateral condyle; anteroposterior distance of the tibial plateaus; tibial slope. In addition, three morphological ratios were calculated. Results Most of the bone morphological parameters were different between genders (P<0.001). Similarly, there were significant differences between ACL-ruptured and control subjects (P<0.001), either for total sample or subgrouped by gender. Logistic regression model showed that 5 bone morphological parameters were significantly associated with ACL rupture (AUC=0.967, P<0.001). The calculated ratios showed significant accuracy in identifying individuals with higher risk of sustaining an ACL injury (P