Extrafine Versus Fine Inhaled Corticosteroids in Relation to Asthma Control: A Systematic Review and Meta-Analysis of Observational Real-Life Studies
- Sonnappa, Samatha
- Mcqueen, Brett
- Postma, Dirkje S
- Martin, Richard J
- Roche, Nicolas
- Grigg, Jonathan
- Guilbert, Theresa
- Gouder, Caroline
- Pizzichini, Emilio
- Niimi, Akio
- Phipatanakul, Wanda
- Chisholm, Alison
- Dandurand, Ronald J
- Kaplan, Alan
- Israel, Elliot
- Papi, Alberto
- van Aalderen, Willem M C
- Usmani, Omar S
- Price, David B
DOIAbstract
BACKGROUND: The particle size of inhaled corticosteroids (ICSs) may affect airway drug deposition and effectiveness. OBJECTIVE: To compare the effectiveness of extrafine ICSs (mass median aerodynamic diameter, <2 μm) versus fine-particle ICSs administered as ICS monotherapy or ICS-long-acting β-agonist combination therapy by conducting a meta-analysis of observational real-life asthma studies to estimate the treatment effect of extrafine ICSs. METHODS: MEDLINE and EMBASE databases were reviewed for asthma observational comparative effectiveness studies from January 2004 to June 2016. Studies were included if they reported odds and relative risk ratios and met all inclusion criteria (Respiratory Effectiveness Group/European Academy ...
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