Type 3 innate lymphoid cells (ILCs) mediate tissue homeostasis and protection, primarily at mucosal sites. Their profile is tightly controlled by the tissue microenvironment and can shift toward production of the type 1 cytokine IFNγ in an inflammatory setting. Likely because ILC3 and natural killer (NK) cells are developmentally divergent innate lymphocyte lineages in mice, the plasticity of ILC3s with respect to cytotoxic function has been neglected. Since RORγt-expressing progenitors, however, contribute to NK cell generation in humans, we aimed to address this knowledge gap both in vitro and in vivo, using humanized mice. We could demonstrate that after exposure to IL-12 and IL-15, human ILC3s up-regulate expression of the master regul...
International audienceInnate lymphoid cells (ILCs) are lineage- and antigen receptor-negative lympho...
International audienceInnate lymphoid cells (ILCs) are lineage- and antigen receptor-negative lympho...
Innate lymphoid cells (ILCs) were firstly described by different independent laboratories in 2008 as...
Type 3 innate lymphoid cells (ILC3s) fulfill protective functions at mucosal surfaces via cytokine p...
Type 3 innate lymphoid cells (ILC3s) are characterized by ROR gamma t expression and they produce IL...
Human ILCs are classically categorized into five subsets; cytotoxic CD127- CD94+ NK cells and non-cy...
Five subsets of ILCs are extensively described, Lymphoid Tissue inducer (LTi) cells, cytotoxic NK ce...
Human ILCs are classically categorized into five subsets; cytotoxic CD127- CD94+ NK cells and non-cy...
Human ILCs are classically categorized into five subsets; cytotoxic CD127- CD94+ NK cells and non-cy...
Human ILCs are classically categorized into five subsets; cytotoxic CD127- CD94+ NK cells and non-cy...
SummaryMucosal innate lymphoid cell (ILC) subsets promote immune responses to pathogens by producing...
Human ILCs are classically categorized into five subsets; cytotoxic CD127−CD94+ NK cells and non-cyt...
Human ILCs are classically categorized into five subsets; cytotoxic CD127−CD94+ NK cells and non-cyt...
International audienceInnate lymphoid cells (ILCs) are lineage- and antigen receptor-negative lympho...
International audienceInnate lymphoid cells (ILCs) are lineage- and antigen receptor-negative lympho...
International audienceInnate lymphoid cells (ILCs) are lineage- and antigen receptor-negative lympho...
International audienceInnate lymphoid cells (ILCs) are lineage- and antigen receptor-negative lympho...
Innate lymphoid cells (ILCs) were firstly described by different independent laboratories in 2008 as...
Type 3 innate lymphoid cells (ILC3s) fulfill protective functions at mucosal surfaces via cytokine p...
Type 3 innate lymphoid cells (ILC3s) are characterized by ROR gamma t expression and they produce IL...
Human ILCs are classically categorized into five subsets; cytotoxic CD127- CD94+ NK cells and non-cy...
Five subsets of ILCs are extensively described, Lymphoid Tissue inducer (LTi) cells, cytotoxic NK ce...
Human ILCs are classically categorized into five subsets; cytotoxic CD127- CD94+ NK cells and non-cy...
Human ILCs are classically categorized into five subsets; cytotoxic CD127- CD94+ NK cells and non-cy...
Human ILCs are classically categorized into five subsets; cytotoxic CD127- CD94+ NK cells and non-cy...
SummaryMucosal innate lymphoid cell (ILC) subsets promote immune responses to pathogens by producing...
Human ILCs are classically categorized into five subsets; cytotoxic CD127−CD94+ NK cells and non-cyt...
Human ILCs are classically categorized into five subsets; cytotoxic CD127−CD94+ NK cells and non-cyt...
International audienceInnate lymphoid cells (ILCs) are lineage- and antigen receptor-negative lympho...
International audienceInnate lymphoid cells (ILCs) are lineage- and antigen receptor-negative lympho...
International audienceInnate lymphoid cells (ILCs) are lineage- and antigen receptor-negative lympho...
International audienceInnate lymphoid cells (ILCs) are lineage- and antigen receptor-negative lympho...
Innate lymphoid cells (ILCs) were firstly described by different independent laboratories in 2008 as...