B lymphocytes are a type of white blood cells, belonging to the adaptive arm of the immune system and involved in creating immunological memory. B cells function in the humoral immune system by secreting antibodies which can bind pathogens to prevent them from doing further damage and to help other immune cells to target them. It is highly important that the immune system can distinguish self from none-self, since an immune response to self-antigens would cause the immune system to attack the hosts own healthy cells and tissues. The development of different B cells subsets is highly complex and both differentiation and proliferation is under strict transcriptional control. Defects in lymphopoiesis can lead to serious disorders like immunode...
B cells are recognized as main actors in the autoimmune process. Autoreactive B cells can arise in t...
The studies described in this thesis help understand why disturbances in specific genes and processe...
Autoantibodies are a common feature of all autoimmune diseases. The molecules against which autoanti...
Our immune system is a complex network made up of physical barriers and specialized proteins, cells...
AbstractThe pathogenic roles of B cells in human autoimmune diseases involve a multitude of mechanis...
The immune system protects individuals against infections but can cause disease if the response is u...
B cells were often thought of as simple precursors of end-stage effector cells that are merely in ch...
B lymphocytes have essential roles in the autoimmune pathogenesis of multiple sclerosis (MS). They r...
Copyright © 2012 Christiane S. Hampe.is is an open access article distributed under theCreativeCommo...
Antibody-secreting cells (ASCs) play a fundamental role in humoral immunity. The aberrant function o...
In mice, B1 and marginal zone (MZ) B-cells play an important role in prevention of autoimmunity thro...
Cardiovascular disease is one of the leading causes of death worldwide. A major cause is atheroscler...
In germinal centres, somatic hypermutation and B cell selection increase antibody affinity and speci...
Abstract Immunologists have long investigated B lymphocytes as solely antibody-producing cells. With...
Ph. D. ThesisRheumatoid arthritis (RA) is a chronic autoimmune disorder characterised by joint infla...
B cells are recognized as main actors in the autoimmune process. Autoreactive B cells can arise in t...
The studies described in this thesis help understand why disturbances in specific genes and processe...
Autoantibodies are a common feature of all autoimmune diseases. The molecules against which autoanti...
Our immune system is a complex network made up of physical barriers and specialized proteins, cells...
AbstractThe pathogenic roles of B cells in human autoimmune diseases involve a multitude of mechanis...
The immune system protects individuals against infections but can cause disease if the response is u...
B cells were often thought of as simple precursors of end-stage effector cells that are merely in ch...
B lymphocytes have essential roles in the autoimmune pathogenesis of multiple sclerosis (MS). They r...
Copyright © 2012 Christiane S. Hampe.is is an open access article distributed under theCreativeCommo...
Antibody-secreting cells (ASCs) play a fundamental role in humoral immunity. The aberrant function o...
In mice, B1 and marginal zone (MZ) B-cells play an important role in prevention of autoimmunity thro...
Cardiovascular disease is one of the leading causes of death worldwide. A major cause is atheroscler...
In germinal centres, somatic hypermutation and B cell selection increase antibody affinity and speci...
Abstract Immunologists have long investigated B lymphocytes as solely antibody-producing cells. With...
Ph. D. ThesisRheumatoid arthritis (RA) is a chronic autoimmune disorder characterised by joint infla...
B cells are recognized as main actors in the autoimmune process. Autoreactive B cells can arise in t...
The studies described in this thesis help understand why disturbances in specific genes and processe...
Autoantibodies are a common feature of all autoimmune diseases. The molecules against which autoanti...