Risk stratification using SpO2/FiO2and PEEP at initial ARDS diagnosis and after 24Â h in patients with moderate or severe ARDS
- Pisani, Luigi
- Roozeman, Jan-Paul
- Simonis, Fabienne D.
- Giangregorio, Antonio
- van der Hoeven, Sophia M.
- Schouten, Laura R.
- Horn, Janneke
- Neto, Ary Serpa
- Festic, Emir
- Dondorp, Arjen M.
- Grasso, Salvatore
- Bos, Lieuwe D.
- Schultz, Marcus J.
- van Hooijdonk, Roosmarijn T. M.
- Huson, Mischa A.
- Schouten, Laura R. A.
- Straat, Marleen
- Simonis, Fabienne D.
- Bos, Lieuwe D.
- van Vught, Lonneke A.
- Wiewel, Maryse A.
- Witteveen, Esther
- Glas, Gerie J.
- Wieske, Luuk
- Frencken, Jos F.
- Bonten, Marc
- Klein Klouwenberg, Peter M. C.
- Ong, David
- Scicluna, Brendon P.
- Hoogendijk, Arjan J.
- Belkasim-Bohoudi, H.
- van der Poll, Tom
DOIAbstract
Background: We assessed the potential of risk stratification of ARDS patients using SpO2/FiO2and positive end-expiratory pressure (PEEP) at ARDS onset and after 24 h. Methods: We used data from a prospective observational study in patients admitted to a mixed medicalâ\u80\u93surgical intensive care unit of a university hospital in the Netherlands. Risk stratification was by cutoffs for SpO2/FiO2and PEEP. The primary outcome was in-hospital mortality. Patients with moderate or severe ARDS with a length of stay of > 24 h were included in this study. Patients were assigned to four predefined risk groups: group I (SpO2/FiO2 â\u89¥Â 190 and PEEP < 10 cm H2O), group II (SpO2/FiO2 â\u89¥Â 190 and PEEP â\u89¥Â 10 cm), group III (SpO2/FiO2...
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