Evidence for early infection of nonneoplastic natural killer cells by Epstein-Barr virus.
- Trempat, Pascal
- Tabiasco, Julie
- Andre, Pascale
- Faumont, Nathalie
- Meggetto, Fabienne
- Delsol, Georges
- Gascoyne, Randy
- Fournié, Jean-Jacques
- Vivier, Eric
- Brousset, Pierre
Publication date
November 2002
DOI Publisher
American Society for MicrobiologyAbstract
International audienceWe examined lymph nodes and tonsils from patients with infectious mononucleosis by combined detection of EBV-encoded RNA and a specific marker of natural killer (NK) cells, PEN5. A small number of Epstein-Barr virus (EBV) latently infected nonneoplastic NK cells were detected. Our data demonstrate that NK cells are natural targets of EBV and that infection of these cells is an early event observed during primary EBV infection
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