Relationship between nickel exposure and the level of carcinoembryonic antigen among welders in an automotive plant

Background: Study on the effect of nickel exposure in the occupational setting and its association to carcinoembryonic antigen (CEA) had been studied before. Questions were raised whether the result from previous study would also show the same pattern of the urinary nickel concentration in this study. Objective: A cross-sectional study was conducted to determine the association between urine nickel concentration and CEA level among welders in automotive part workers in Malaysia. Methodology: There were 56 welders and 44 administrative workers were recruited in this study. Urine and blood samples were collected at the end of shift towards the end of workweek. CEA was assayed in serum using TECO Diagnostic ELISA Kit. Urinary nickel was determined by Graphite Furnace Atomic Absorption Spectrophotometer. Results: The mean carcinoembryonic antigen concentrations of the exposed group (4.07±2.60 ng mL-1) was significantly higher (p<0.001) than the control group (1.99±0.97 ng mL-1). Twenty seven percent of the exposed group showed values above the reference range. The mean urinary nickel level was also significantly higher (p