Add to ORKGIn previous studies we have developed a novel spinal subpial (SP) AAV delivery technique in adult mice, rats and minipigs. Using this technique we have demonstrated potent and wide-spread transgene (GFP) expression in spinal white and gray matter after a single SP bolus of AAV9-UBI-GFP
Spinal muscular atrophy (SMA) is the most frequent lethal genetic neurodegenerative disorder in infa...
Targeting lower motor neurons (LMNs) for gene delivery could be useful for disorders such as spinal ...
Injection of AAV into the cerebrospinal fluid (CSF) offers a means to achieve widespread transgene d...
Gene silencing with virally delivered shRNA represents a promising approach for treatment of inherit...
Effective in vivo use of adeno-associated virus (AAV)-based vectors to achieve gene-specific silenci...
The introduction of therapeutic genes to neurons by genetic modification has potential as an effecti...
receptor agonist), while effective in modulating spasticity is associated with major side effects s...
Second-order spinal cord excitatory neurons play a key role in spinal processing and transmission of...
Adeno-associated virus (AAV) gene therapy constitutes a powerful tool for the treatment of neurodege...
The capacity of certain adeno-associated virus (AAV) vectors to cross the blood–brain barrier after ...
Abstract Background Gene transfer to nociceptive neurons of the dorsal root ganglia (DRG) is a promi...
Until recently, adeno-associated virus 9 (AAV9) was considered the AAV serotype most effective in cr...
Recently, we demonstrated that the administration of GAD65-expressing rAAV2 to DRG attenuates periph...
Adeno-associated viral (AAV) vectors have shown promise as a platform for gene therapy of neurologic...
<p>The HiRet, NeuRet, and RV-G-pseudotyped vectors encoding the GFP transgene with equivalent RNA ti...
Spinal muscular atrophy (SMA) is the most frequent lethal genetic neurodegenerative disorder in infa...
Targeting lower motor neurons (LMNs) for gene delivery could be useful for disorders such as spinal ...
Injection of AAV into the cerebrospinal fluid (CSF) offers a means to achieve widespread transgene d...
Gene silencing with virally delivered shRNA represents a promising approach for treatment of inherit...
Effective in vivo use of adeno-associated virus (AAV)-based vectors to achieve gene-specific silenci...
The introduction of therapeutic genes to neurons by genetic modification has potential as an effecti...
receptor agonist), while effective in modulating spasticity is associated with major side effects s...
Second-order spinal cord excitatory neurons play a key role in spinal processing and transmission of...
Adeno-associated virus (AAV) gene therapy constitutes a powerful tool for the treatment of neurodege...
The capacity of certain adeno-associated virus (AAV) vectors to cross the blood–brain barrier after ...
Abstract Background Gene transfer to nociceptive neurons of the dorsal root ganglia (DRG) is a promi...
Until recently, adeno-associated virus 9 (AAV9) was considered the AAV serotype most effective in cr...
Recently, we demonstrated that the administration of GAD65-expressing rAAV2 to DRG attenuates periph...
Adeno-associated viral (AAV) vectors have shown promise as a platform for gene therapy of neurologic...
<p>The HiRet, NeuRet, and RV-G-pseudotyped vectors encoding the GFP transgene with equivalent RNA ti...
Spinal muscular atrophy (SMA) is the most frequent lethal genetic neurodegenerative disorder in infa...
Targeting lower motor neurons (LMNs) for gene delivery could be useful for disorders such as spinal ...
Injection of AAV into the cerebrospinal fluid (CSF) offers a means to achieve widespread transgene d...