Expression of cell cycle progression-related genes, ribosome biogenesis, and cyclins and cyclin-dependent kinases (CDKs).

<p>(<b>A</b>) Data show average standardized transcript abundance (across Fe conditions) in WGCNA co-expression modules enriched for gene functions associated with cell cycle progression (tan–selected genes see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006490#pgen.1006490.s001" target="_blank">S1 Dataset</a>, darkgreen) and ribosome biogenesis (darkgrey) genes at 20, 40, and 400 pM Fe′ with shaded area indicating one standard deviation (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006490#pgen.1006490.s001" target="_blank">S1 Dataset</a> for gene IDs). (<b>B</b>) Cyclin and CDK transcript abundance. Waves of co-expressed cyclins and CDKs were identified with hierarchical clustering (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006490#pgen.1006490.s015" target="_blank">S10 Fig</a>). Standardized cluster averages (within each Fe condition, positive values only) are shown. (<b>C</b>) Transcript abundance (RPKM) of wave 1 cyclins and dsCYC2-regulating transcription factors (bZIP10 and Aureo1a) are shown. Dashed lines indicate data are plotted on the secondary y-axis.