Viral genome sequences and virus-specific CD8⁺ T-cell responses in 3pSIV-infected <i>90-120-Ia</i>^- macaques.

<p><b>A.</b> Dominant nonsynonymous mutations in plasma viruses obtained from 3pSIV-infected <i>90-120-Ia</i>^- macaques at 1 year (in #421, #422, #423, and #424) or at euthanasia 10–11 months (in #425 and #426) post-infection. Amino acid substitutions from wild-type SIVmac239 sequences are shown by bars. Black bars indicate the mutations selected in 1pSIV. Red triangles indicate the mutations resulting in escape from <i>90-120-Ia</i>-associated CD8⁺ T-cell recognition. <b>B.</b> SIV antigen-specific CD8⁺ T-cell responses in 3pSIV-infected <i>90-120-Ia</i>^- macaques at 3 and 9 months after 3pSIV infection.