Post-weaning high-fat diet results in growth cartilage lesions in young male rats - Fig 3

<p>(A) Representative sections of Grade 0 and Grade 1 lesions from all 4 groups. (B) Grade 2 lesions were detected in high fat-fed rats only (total of 4 lesions detected) * indicates regions of fibrosis at the interface of the subchondral bone and EPG lesion; arrows indicate fissures within the lesion. (C) Incidence (%) of rats in which one or more lesions were detected. (D) Mean (±SEM) severity score (sum of grades from all 6 sites examined in each joint). n = 8 for SED groups, n = 10 for EX groups. * p < 0.05, **p < 0.01, ***p < 0.001. * indicates comparisons between chow and HF diets and + indicates comparisons between exercised groups.