A and B. Influence of the aptamer BC 007 on the activity of autoantibodies directed against the G-protein coupled receptors (GPCR-AABs) specifically those to the β2-adrenergic (β2-AABs), α1-adrenergic (a1-AABs) and endothelin A receptor (ETA-AABs) in patients with (A) vascular (β2-AABs, α1-AABs, ETA-AABs) and (B) Alzheimer’s dementia (β2-AABs, α1-AABs).

<p>The total chronotropic activity of the patients’ IgG as well as the activities related to each autoantibody on spontaneously beating cultured neonatal rat cardiomyocytes isolated from the serum of all 4 patients in the absence (colored columns) and presence (0.1 μM) of BC 007 (grey columns) are demonstrated. For each one of the patients with vascular and Alzheimer’s dementia, the GPCR-AAB activity in the presence of a scrambled 15 mer aptamer is additionally demonstrated. Values below the low limit of detection (black line = LLD) were displayed as half range values. LLD = 4 beats/min and—4 beats/min, respective.