Canonical pathways correlated with the Alzheimer’s disease curated list.

<p>The ADCL is colored in blue. Neighbors without genes in common with the ADCL are highlighted in green. The shape of the node corresponds to the pathway database. For the coexpression network, the edge color indicates the value of the correlation and the edge width is proportional to the correlation magnitude. For the overlap network, the edge width is proportional to the overlap coefficient. (A) Pathway coexpression network for the top pathways correlated with the ADCL (by correlation magnitude). All correlated pathways have established associations with AD: <i>GPVI Mediated Activation Cascade</i> [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006042#pcbi.1006042.ref079" target="_blank">79</a>], IL-3, 5 and GM-CSF signalling [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006042#pcbi.1006042.ref080" target="_blank">80</a>], <i>Antigen Processing Cross Presentation</i> [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006042#pcbi.1006042.ref081" target="_blank">81</a>], <i>PDGFRB Pathway</i> [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006042#pcbi.1006042.ref083" target="_blank">83</a>], <i>Toll Pathway</i> [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006042#pcbi.1006042.ref084" target="_blank">84</a>], <i>Regulation of Signaling by CBL</i> [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006042#pcbi.1006042.ref082" target="_blank">82</a>], <i>Toll-like Receptor Signaling</i> [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006042#pcbi.1006042.ref085" target="_blank">85</a>], <i>Activation of IRF3/IRF7 Mediated by TBK1/IKK Epsilon</i> [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006042#pcbi.1006042.ref085" target="_blank">85</a>], <i>Cell Surface Interactions at the Vascular Wall</i> [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006042#pcbi.1006042.ref086" target="_blank">86</a>], <i>FCER1 Pathway</i> [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006042#pcbi.1006042.ref087" target="_blank">87</a>]. (B) Shared genes (overlap coefficient) between the top pathways correlated with the ADCL. (C) Correlation magnitude of all canonical pathways correlated with the ADCL sorted by the magnitude of their correlation and split in bins of increasing size. (D) Proportion of canonical pathways enriched for the genes within the ADCL (<i>p</i> < 0.001, adjusted with FDR) present in the canonical pathways correlated with the ADCL (E) Proportion of canonical pathways enriched for genes associated with AD from the Genetic Association Database present in the pathways correlated with the ADCL (<i>p</i> < 0.001, adjusted with FDR). The red line indicates the proportion of all 1,330 canonical pathways enriched for genes within the ADCL.