EGCG does not influence sociability or anxiety-related behavior in CD mice.

<p>(a) In a direct social test, CD mice fed with green tea behaved in the same way that water fed CD mice towards an intruder mice. A two-way ANOVA indicated a significant main effect of genotype (F_1,37 = 19.86, <i>p</i><0.0001), without effect of treatment (F_1,37 = 0.00044, <i>p</i> = 0.9834). n = 7–15 per group. White, WT; Black, CD. Plain, water; Striped, EGCG. Data are presented as the mean ± SEM. (b) Anxiety-like behavior was evaluated in the marble-burying test. A three-way ANOVA revealed no interaction between genotype, treatment and time (F_3,128 = 1.380, <i>p</i> = 0.252), with a significant main effect of genotype (F_1,128 = 306.684, <i>p</i><0.0001) and time (F_3,128 = 17.170, <i>p</i><0.0001) but no effect of treatment (F_1,128 = 0.182, <i>p</i> = 0.670). n = 8–10 per group. Squares, WT; Circles, CD. White and black, water; Green, EGCG fed mice. <i>p</i> values are shown with asterisks (genotype effect) indicating values that are significantly different in a two-way ANOVA with Bonferroni <i>post hoc</i> test (***<i>p</i><0.001).