Effect of EGCG on hippocampal synaptic plasticity markers.

<p>(a) EGCG treatment normalized <i>Bdnf</i> mRNA levels in CD animals. A two-way ANOVA indicated a significant interaction between genotypes and treatment (F_1,38 = 5.512, <i>p</i> = 0.0242), with a significant effect of genotype (F_1,38 = 6.599, <i>p</i> = 0.0143) and treatment (F_1,38 = 30.47, <i>p</i><0.0001). (b) EGCG treatment did not normalize the high <i>Pik3r1</i> mRNA levels observed in the hippocampus of CD mice. A two-way ANOVA indicated a significant effect of treatment (F_1,24 = 7.406, <i>p</i> = 0.0119), since EGCG treatment upregulated <i>Pik3r1</i> mRNA levels in WT animals. n = 6–13 per group. <i>p</i> values are shown with asterisks (genotype) or hashes (treatment) indicating values that are significantly different (two-way ANOVA with Bonferroni <i>post hoc</i> test). *,^#<i>p</i><0.05; **,^##<i>p</i><0.01; ***,^###<i>p</i><0.001. White, WT; Black, CD. Plain, water; Striped, EGCG. Data are presented as the mean ± SEM.