EGCG does not influence brain abnormalities present in CD mice.

<p>(a) Brain weight of water or EGCG fed CD mice was significantly reduced when compared to WT mice. A two-way ANOVA indicated a significant effect of genotype (F_1,37 = 40.72, <i>p</i><0.0001) but no effect of treatment (F_1,37 = 0.3766, <i>p</i> = 0.5432). (b) Dendrite length of CA1 neurons was measured in stratum radiatum (SR). A two-way ANOVA indicated a significant effect of genotype (F_1,37 = 15.98, <i>p</i> = 0.0003) but not effect of treatment (F_1,37 = 1.728, <i>p</i> = 0.1968) (c) Dendrite length of CA1 neurons was measured in stratum oriens (SO). A two-way ANOVA indicated a deleterious effect of treatment in the case of WT mice (F_1,37 = 22.92, <i>p</i><0.0001 with <i>p</i><0.001 Bonferroni <i>post hoc</i> test). (d) EGCG treatment did not increase the number of spines present in apical dendrites of CD neurons. A two-way ANOVA indicated a significant effect of genotype (F_1,37 = 13.13, <i>p</i> = 0.0009) without treatment effect (F_1,37 = 1.722, <i>p</i> = 0.1976). n = 8–13 mice per group. <i>p</i> values are shown with asterisks (genotype) or hashes (treatment) indicating values that are significantly different (two-way ANOVA with Bonferroni <i>post hoc</i> test). *,^#<i>p</i><0.05; **,^##<i>p</i><0.01; ***,^###<i>p</i><0.001. White, WT; Black, CD. Plain, water; Striped, EGCG fed mice. Data are presented as the mean ± SEM.