Schematic diagram of the role of miR-203-3p in the initiation of type 2 pathology after infection.

<p>Infection induces the down-regulation of miR-203-3p in HSCs, resulting in the elevation of IL-33. Extracellular IL-33 stimulates the expansion and IL-13 production of hepatic ILC2s. Elevated IL-13 then activates HSCs to produce excessive collagen through activation of the STAT6 pathway.