Additional file 4: of Induction of apoptosis in imatinib sensitive and resistant chronic myeloid leukemia cells by efficient disruption of bcr-abl oncogene with zinc finger nucleases

Additional file 6: of Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Supplementary materials and methods. Description and results of cell line fingerprinting, Flow cytom...

Additional file 1: of Targeting chemotherapy-resistant leukemia by combining DNT cellular therapy with conventional chemotherapy

Branson Chen (292927)
Jong Lee (3448640)
Hyeonjeong Kang (5141006)
Mark Minden (237041)
Li Zhang (8200)

April 2018

Figure S1. Gating strategy for 2 h flow-based cytotoxicity assay. Target cells were stained with PKH...

Additional file 3: of Selective activation of TNFR1 and NF-κB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells

Christiana Savva (3490505)
Sotirios Totokotsopoulos (2033767)
Kyriakos Nicolaou (3490502)
Christiana Neophytou (3490499)
Andreas Constantinou (3490496)

April 2016

KC-53 induces DNA damage in HL-60 and CCRF/CEM cells. HL-60 and CCRF/CEM cells were treated with veh...

Additional file 5: of Induction of apoptosis in imatinib sensitive and resistant chronic myeloid leukemia cells by efficient disruption of bcr-abl oncogene with zinc finger nucleases

Ningshu Huang (3429020)
Zhenglan Huang (402997)
Miao Gao (3429014)
Zhenhong Luo (3429023)
Fangzhu Zhou (4978493)
Lin Liu (74495)
Qing Xiao (402996)
Xin Wang (91924)
Wenli Feng (403001)

March 2018

Figure S5. Supporting data for Fig. 4. (A) The colony formation ability of K562 and K562/G01 cells w...

Additional file 2: of Induction of apoptosis in imatinib sensitive and resistant chronic myeloid leukemia cells by efficient disruption of bcr-abl oncogene with zinc finger nucleases

Ningshu Huang (3429020)
Zhenglan Huang (402997)
Miao Gao (3429014)
Zhenhong Luo (3429023)
Fangzhu Zhou (4978493)
Lin Liu (74495)
Qing Xiao (402996)
Xin Wang (91924)
Wenli Feng (403001)

March 2018

Figure S2. Supporting data for Fig. 2. (A) K562 cells were treated with ZFN-L and ZFN-R for 48 h and...

Additional file 1: of Induction of apoptosis in imatinib sensitive and resistant chronic myeloid leukemia cells by efficient disruption of bcr-abl oncogene with zinc finger nucleases

Ningshu Huang (3429020)
Zhenglan Huang (402997)
Miao Gao (3429014)
Zhenhong Luo (3429023)
Fangzhu Zhou (4978493)
Lin Liu (74495)
Qing Xiao (402996)
Xin Wang (91924)
Wenli Feng (403001)

March 2018

Figure S1. Expression of ZFNs proteins in K562 cells. (A) The proteins of K562 cells were collected ...

Additional file 3: of Induction of apoptosis in imatinib sensitive and resistant chronic myeloid leukemia cells by efficient disruption of bcr-abl oncogene with zinc finger nucleases

Ningshu Huang (3429020)
Zhenglan Huang (402997)
Miao Gao (3429014)
Zhenhong Luo (3429023)
Fangzhu Zhou (4978493)
Lin Liu (74495)
Qing Xiao (402996)
Xin Wang (91924)
Wenli Feng (403001)

March 2018

Figure S3. Supporting data for Fig. 3. (A), (B) Quantification of protein from the experiments, norm...

Additional file 1 of A conserved ZFX/WNT3 axis modulates the growth and imatinib response of chronic myeloid leukemia stem/progenitor cells

Xiuyan Zhang (511881)
Yu Wang (12152)
Jinchang Lu (9162470)
Lun Xiao (12186593)
Hui Chen (28597)
Quanxue Li (5140934)
Yuan-Yuan Li (27693)
Peng Xu (17962)
Changgeng Ruan (328282)
Haixia Zhou (128581)
Yun Zhao (17263983)

October 2023

Additional file 1: Table S1. The clinical characteristics of chronic myeloid leukemia patients recru...

Additional file 1 of Synergistic lethality in chronic myeloid leukemia – targeting oxidative phosphorylation and unfolded protein response effectively complements tyrosine kinase inhibitor treatment

Lukas Häselbarth (17461169)
Sara Gamali (17461172)
Domenica Saul (5933270)
Manuela Krumbholz (282787)
Romy Böttcher-Loschinski (17461175)
Martin Böttcher (4609738)
Deyu Zou (401646)
Markus Metzler (59320)
Axel Karow (9540293)
Dimitrios Mougiakakos (149682)

November 2023

Additional file 1: Supplementary Table 1. Inhibitor concentrations. Supplementary Table 2. Antibodie...

Additional file 4: of Selective activation of TNFR1 and NF-κB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells

Christiana Savva (3490505)
Sotirios Totokotsopoulos (2033767)
Kyriakos Nicolaou (3490502)
Christiana Neophytou (3490499)
Andreas Constantinou (3490496)

April 2016

KC-53 does not promote the generation of reactive oxygen species in leukemic cells. HL-60 and CCRF/C...

Additional file 4: of Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Figure S4. Targeting TRAIL in HCC1954-Par and -L cells. A) Western blot and densitometry for pAKT (S...

MOESM1 of Bortezomib-mediated downregulation of S-phase kinase protein-2 (SKP2) causes apoptotic cell death in chronic myelogenous leukemia cells

Ahmad Iskandarani (3520067)
Ajaz Bhat (3520058)
Kodappully Siveen (3520073)
Kirti Prabhu (3520064)
Shilpa Kuttikrishnan (3520079)
Muzammil Khan (3520076)
Roopesh Krishnankutty (1297770)
Michal Kulinski (3520070)
Rihab Nasr (631071)
Ramzi Mohammad (3520061)
Shahab Uddin (154400)

March 2016

Additional file 1: Figure S1. Bortezomib-mediated induction of early (Annexin +ive and PI −ive cells...

Additional file 3 of Pharmacologic targeting of the P-TEFb complex as a therapeutic strategy for chronic myeloid leukemia

Yingjie Qing (11251985)
Xiangyuan Wang (1960876)
Hongzheng Wang (3094824)
Po Hu (2326930)
Hui Li (32376)
Xiaoxuan Yu (11251988)
Mengyuan Zhu (1691809)
Zhanyu Wang (11251991)
Yu Zhu (250261)
Jingyan Xu (3840085)
Qinglong Guo (533364)
Hui Hui (11251994)

August 2021

Additional file 3. Figure S3. Apoptosis detection of KU-812 cells by TUNEL (a) KU-812 cells were tre...

Additional file 7: of Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Expression data for differentially expressed apoptosis related genes in SKBR3 and SKBR3-L cells. Exp...

Additional file 1: of Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Figure S1. Percentage apoptosis induction by obatoclax and/or lapatinib in HCC1954-Par and HCC1954-L...

Additional file 6: of Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Supplementary materials and methods. Description and results of cell line fingerprinting, Flow cytom...

Additional file 1: of Targeting chemotherapy-resistant leukemia by combining DNT cellular therapy with conventional chemotherapy

Branson Chen (292927)
Jong Lee (3448640)
Hyeonjeong Kang (5141006)
Mark Minden (237041)
Li Zhang (8200)

April 2018

Figure S1. Gating strategy for 2 h flow-based cytotoxicity assay. Target cells were stained with PKH...

Additional file 3: of Selective activation of TNFR1 and NF-κB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells

Christiana Savva (3490505)
Sotirios Totokotsopoulos (2033767)
Kyriakos Nicolaou (3490502)
Christiana Neophytou (3490499)
Andreas Constantinou (3490496)

April 2016

KC-53 induces DNA damage in HL-60 and CCRF/CEM cells. HL-60 and CCRF/CEM cells were treated with veh...

Additional file 5: of Induction of apoptosis in imatinib sensitive and resistant chronic myeloid leukemia cells by efficient disruption of bcr-abl oncogene with zinc finger nucleases

Ningshu Huang (3429020)
Zhenglan Huang (402997)
Miao Gao (3429014)
Zhenhong Luo (3429023)
Fangzhu Zhou (4978493)
Lin Liu (74495)
Qing Xiao (402996)
Xin Wang (91924)
Wenli Feng (403001)

March 2018

Figure S5. Supporting data for Fig. 4. (A) The colony formation ability of K562 and K562/G01 cells w...

Additional file 2: of Induction of apoptosis in imatinib sensitive and resistant chronic myeloid leukemia cells by efficient disruption of bcr-abl oncogene with zinc finger nucleases

Ningshu Huang (3429020)
Zhenglan Huang (402997)
Miao Gao (3429014)
Zhenhong Luo (3429023)
Fangzhu Zhou (4978493)
Lin Liu (74495)
Qing Xiao (402996)
Xin Wang (91924)
Wenli Feng (403001)

March 2018

Figure S2. Supporting data for Fig. 2. (A) K562 cells were treated with ZFN-L and ZFN-R for 48 h and...

Additional file 1: of Induction of apoptosis in imatinib sensitive and resistant chronic myeloid leukemia cells by efficient disruption of bcr-abl oncogene with zinc finger nucleases

Ningshu Huang (3429020)
Zhenglan Huang (402997)
Miao Gao (3429014)
Zhenhong Luo (3429023)
Fangzhu Zhou (4978493)
Lin Liu (74495)
Qing Xiao (402996)
Xin Wang (91924)
Wenli Feng (403001)

March 2018

Figure S1. Expression of ZFNs proteins in K562 cells. (A) The proteins of K562 cells were collected ...

Additional file 3: of Induction of apoptosis in imatinib sensitive and resistant chronic myeloid leukemia cells by efficient disruption of bcr-abl oncogene with zinc finger nucleases

Ningshu Huang (3429020)
Zhenglan Huang (402997)
Miao Gao (3429014)
Zhenhong Luo (3429023)
Fangzhu Zhou (4978493)
Lin Liu (74495)
Qing Xiao (402996)
Xin Wang (91924)
Wenli Feng (403001)

March 2018

Figure S3. Supporting data for Fig. 3. (A), (B) Quantification of protein from the experiments, norm...

Additional file 1 of A conserved ZFX/WNT3 axis modulates the growth and imatinib response of chronic myeloid leukemia stem/progenitor cells

Xiuyan Zhang (511881)
Yu Wang (12152)
Jinchang Lu (9162470)
Lun Xiao (12186593)
Hui Chen (28597)
Quanxue Li (5140934)
Yuan-Yuan Li (27693)
Peng Xu (17962)
Changgeng Ruan (328282)
Haixia Zhou (128581)
Yun Zhao (17263983)

October 2023

Additional file 1: Table S1. The clinical characteristics of chronic myeloid leukemia patients recru...

Additional file 1 of Synergistic lethality in chronic myeloid leukemia – targeting oxidative phosphorylation and unfolded protein response effectively complements tyrosine kinase inhibitor treatment

Lukas Häselbarth (17461169)
Sara Gamali (17461172)
Domenica Saul (5933270)
Manuela Krumbholz (282787)
Romy Böttcher-Loschinski (17461175)
Martin Böttcher (4609738)
Deyu Zou (401646)
Markus Metzler (59320)
Axel Karow (9540293)
Dimitrios Mougiakakos (149682)

November 2023

Additional file 1: Supplementary Table 1. Inhibitor concentrations. Supplementary Table 2. Antibodie...

Additional file 4: of Selective activation of TNFR1 and NF-κB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells

Christiana Savva (3490505)
Sotirios Totokotsopoulos (2033767)
Kyriakos Nicolaou (3490502)
Christiana Neophytou (3490499)
Andreas Constantinou (3490496)

April 2016

KC-53 does not promote the generation of reactive oxygen species in leukemic cells. HL-60 and CCRF/C...

Additional file 4: of Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Figure S4. Targeting TRAIL in HCC1954-Par and -L cells. A) Western blot and densitometry for pAKT (S...

MOESM1 of Bortezomib-mediated downregulation of S-phase kinase protein-2 (SKP2) causes apoptotic cell death in chronic myelogenous leukemia cells

Ahmad Iskandarani (3520067)
Ajaz Bhat (3520058)
Kodappully Siveen (3520073)
Kirti Prabhu (3520064)
Shilpa Kuttikrishnan (3520079)
Muzammil Khan (3520076)
Roopesh Krishnankutty (1297770)
Michal Kulinski (3520070)
Rihab Nasr (631071)
Ramzi Mohammad (3520061)
Shahab Uddin (154400)

March 2016

Additional file 1: Figure S1. Bortezomib-mediated induction of early (Annexin +ive and PI −ive cells...

Additional file 3 of Pharmacologic targeting of the P-TEFb complex as a therapeutic strategy for chronic myeloid leukemia

Yingjie Qing (11251985)
Xiangyuan Wang (1960876)
Hongzheng Wang (3094824)
Po Hu (2326930)
Hui Li (32376)
Xiaoxuan Yu (11251988)
Mengyuan Zhu (1691809)
Zhanyu Wang (11251991)
Yu Zhu (250261)
Jingyan Xu (3840085)
Qinglong Guo (533364)
Hui Hui (11251994)

August 2021

Additional file 3. Figure S3. Apoptosis detection of KU-812 cells by TUNEL (a) KU-812 cells were tre...

Additional file 7: of Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Expression data for differentially expressed apoptosis related genes in SKBR3 and SKBR3-L cells. Exp...

Additional file 1: of Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Figure S1. Percentage apoptosis induction by obatoclax and/or lapatinib in HCC1954-Par and HCC1954-L...

Additional file 6: of Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL

Alex Eustace (5515580)
Neil Conlon (4012034)
Martina McDermott (5844752)
Brigid Browne (5844755)
Patrick O’Leary (2112757)
Frankie Holmes (5844758)
Virginia Espina (209337)
Lance Liotta (238260)
Joyce O’Shaughnessy (5844761)
Clair Gallagher (419255)
Lorraine O’Driscoll (112362)
Sweta Rani (112339)
Stephen Madden (2611069)
Neil O’Brien (5844764)
Charles Ginther (5844767)
Dennis Slamon (70141)
Naomi Walsh (5844770)
William Gallagher (4283029)
Radoslaw Zagozdzon (5844773)
William Watson (112355)
Norma O’Donovan (2074084)
John Crown (112358)

October 2018

Supplementary materials and methods. Description and results of cell line fingerprinting, Flow cytom...

Additional file 1: of Targeting chemotherapy-resistant leukemia by combining DNT cellular therapy with conventional chemotherapy

Branson Chen (292927)
Jong Lee (3448640)
Hyeonjeong Kang (5141006)
Mark Minden (237041)
Li Zhang (8200)

April 2018

Figure S1. Gating strategy for 2 h flow-based cytotoxicity assay. Target cells were stained with PKH...

Additional file 3: of Selective activation of TNFR1 and NF-κB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells

Christiana Savva (3490505)
Sotirios Totokotsopoulos (2033767)
Kyriakos Nicolaou (3490502)
Christiana Neophytou (3490499)
Andreas Constantinou (3490496)

April 2016

KC-53 induces DNA damage in HL-60 and CCRF/CEM cells. HL-60 and CCRF/CEM cells were treated with veh...

Additional file 4: of Induction of apoptosis in imatinib sensitive and resistant chronic myeloid leukemia cells by efficient disruption of bcr-abl oncogene with zinc finger nucleases

Abstract

Extracted data

Additional file 4: of Induction of apoptosis in imatinib sensitive and resistant chronic myeloid leukemia cells by efficient disruption of bcr-abl oncogene with zinc finger nucleases

Abstract

Extracted data

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