Additional file 4: of Methotrexate upregulates circadian transcriptional factors PAR bZIP to induce apoptosis on rheumatoid arthritis synovial fibroblasts

Clinical pharmacogenetic model to predict response of MTX monotherapy in patients with established rheumatoid arthritis after DMARD failure.

Fransen, J.
Kooloos, W.M.
Wessels, J.A.M.
Huizinga, T.W.J.
Guchelaar (LUMC), H.J.
Riel, P.L.C.M. van
Barrera, P.

January 2012

Contains fulltext : 110572.pdf (publisher's version ) (Closed access)Background: T...

Additional file 1: of 1,25(OH)2D3 and dexamethasone additively suppress synovial fibroblast activation by CCR6+ T helper memory cells and enhance the effect of tumor necrosis factor alpha blockade

Wendy Dankers (5776064)
Claudia GonzĂĄlez-Leal (5776082)
Nadine Davelaar (5776070)
Patrick Asmawidjaja (5776073)
Adriana Mus (5776076)
Johanna Hazes (3502799)
Edgar Colin (5776079)
Erik Lubberts (26108)

September 2018

Table S1. Characteristics of patients used in this study. Figure S1. 1,25(OH)2D3 and DEX minimally a...

SUMMARY

August 2016

Methotrexate (MTX) levels were studied following intravenous MTX in both serum and synovial fluid (S...

Additional file 2: of Methotrexate upregulates circadian transcriptional factors PAR bZIP to induce apoptosis on rheumatoid arthritis synovial fibroblasts

Kohjin Suzuki (4996409)
Kohsuke Yoshida (4996400)
Takeshi Ueha (119906)
Kenta Kaneshiro (4996394)
Ayako Nakai (4996385)
Naonori Hashimoto (4996415)
Koto Uchida (4996403)
Teppei Hashimoto (4996412)
Yoshiko Kawasaki (4996406)
Nao Shibanuma (4996388)
Natsuko Nakagawa (4996391)
Yoshitada Sakai (119945)
Akira Hashiramoto (4996397)

March 2018

Detailed information of patients with RA enrolled in this study. Joint samples obtained from 10 diff...

Additional file 5: of Methotrexate upregulates circadian transcriptional factors PAR bZIP to induce apoptosis on rheumatoid arthritis synovial fibroblasts

Kohjin Suzuki (4996409)
Kohsuke Yoshida (4996400)
Takeshi Ueha (119906)
Kenta Kaneshiro (4996394)
Ayako Nakai (4996385)
Naonori Hashimoto (4996415)
Koto Uchida (4996403)
Teppei Hashimoto (4996412)
Yoshiko Kawasaki (4996406)
Nao Shibanuma (4996388)
Natsuko Nakagawa (4996391)
Yoshitada Sakai (119945)
Akira Hashiramoto (4996397)

March 2018

The mRNA expression of circadian clock genes over time. mRNA expression of circadian clock genes mea...

Additional file 3: of Methotrexate upregulates circadian transcriptional factors PAR bZIP to induce apoptosis on rheumatoid arthritis synovial fibroblasts

Kohjin Suzuki (4996409)
Kohsuke Yoshida (4996400)
Takeshi Ueha (119906)
Kenta Kaneshiro (4996394)
Ayako Nakai (4996385)
Naonori Hashimoto (4996415)
Koto Uchida (4996403)
Teppei Hashimoto (4996412)
Yoshiko Kawasaki (4996406)
Nao Shibanuma (4996388)
Natsuko Nakagawa (4996391)
Yoshitada Sakai (119945)
Akira Hashiramoto (4996397)

March 2018

Plasmid constructs of Per2/Bik promoter. D-box(+), plasmid constructs containing D-box. D-box(−), pl...

Methotrexate upregulates circadian transcriptional factors PAR bZIP to induce apoptosis on rheumatoid arthritis synovial fibroblasts

Kohjin Suzuki
Kohsuke Yoshida
Takeshi Ueha
Kenta Kaneshiro
Ayako Nakai
Naonori Hashimoto
Koto Uchida
Teppei Hashimoto
Yoshiko Kawasaki
Nao Shibanuma
Natsuko Nakagawa
Yoshitada Sakai
Akira Hashiramoto

March 2018

Abstract Background Effects of methotrexate (MTX) on the proliferation of rheumatoid arthritis (RA) ...

Additional file 1: of Autophagy induction contributes to the resistance to methotrexate treatment in rheumatoid arthritis fibroblast-like synovial cells through high mobility group box chromosomal protein 1

Ke Xu (134879)
Yong-song Cai (3529418)
She-Min Lu (3529421)
Xiao-li Li (3529424)
Lin Liu (74495)
Zhong Li (324520)
Hui Liu (33624)
Peng Xu (17962)

December 2015

The expression of P62 in RA-FLS and OA-FLS treated with 0.1ÎźM MTX for the indicated times (TIF 698 ...

Additional file 1: Figure S1. of MMP-3 as a predictor for structural remission in RA patients treated with MTX monotherapy

Kazuko Shiozawa (3555578)
Takashi Yamane (727284)
Miki Murata (3041562)
Ryosuke Yoshihara (3555581)
Ken Tsumiyama (255552)
Shigeaki Imura (3555575)
Shunichi Shiozawa (255561)

February 2016

Annual changes in disease activity score in 28 joints-erythrocyte sedimentation rate (DAS28-ESR) and...

Additional file 1: of Recapitulation of methotrexate hepatotoxicity with induced pluripotent stem cell-derived hepatocytes from patients with rheumatoid arthritis

Juryun Kim (3428045)
Yena Kim (1713244)
Jinhyeok Choi (6164660)
Hyerin Jung (3428042)
Kijun Lee (4888660)
Jaewoo Kang (239124)
Narae Park (4635103)
Yeri Rim (3428039)
Yoojun Nam (3428033)
Ji Ju (3428051)

December 2018

Immunochemisty and AP staining of iPSCs. a, b Immunocytochemistry of HC- and RA-iPSCs. HC: healthy c...

Additional file 2: of Recapitulation of methotrexate hepatotoxicity with induced pluripotent stem cell-derived hepatocytes from patients with rheumatoid arthritis

Juryun Kim (3428045)
Yena Kim (1713244)
Jinhyeok Choi (6164660)
Hyerin Jung (3428042)
Kijun Lee (4888660)
Jaewoo Kang (239124)
Narae Park (4635103)
Yeri Rim (3428039)
Yoojun Nam (3428033)
Ji Ju (3428051)

December 2018

Generation of iPSC-derived hepatocyte-like cells. a, b Morphology and immunocytochemistry images of ...

Drug survival, efficacy and toxicity of monotherapy with a fully human anti-tumour necrosis factor-alpha antibody compared with methotrexate in long-standing rheumatoid arthritis.

Barrera Rico, P.
Maas, A. van der
Ede, A.E. van
Kiemeney, L.A.L.M.
Laan, R.F.J.M.
Putte, L.B.A. van de
Riel, P.L.C.M. van

January 2002

Contains fulltext : 187532.pdf (publisher's version ) (Closed access)OBJECTIVES: T...

Homocysteine and folate status in methotrexate-treated patients with rheumatoid arthritis.

Ede, A.E. van
Laan, R.F.J.M.
Blom, H.J.
Boers, G.H.J.
Haagsma, C.J.
Thomas, C.M.G.
Boo, T.M. de
Putte, L.B.A. van de

January 2002

Contains fulltext : 142827.pdf (publisher's version ) (Closed access)OBJECTIVE: To...

The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules

Johnston, Andrew
Gudjonsson, Johann Eli
Sigmundsdottir, Hekla
Ludviksson, Bjorn Runar
Valdimarsson, Helgi

January 2005

To access publisher full text version of this article. Please click on the hyperlink in Additional L...

Additional file 1: of The rapid kinetics of optimal treatment with subcutaneous methotrexate in early inflammatory arthritis: an observational study

Anna O’Connor (3117774)
Carter Thorne (3508292)
Hyeon Kang (3508295)
Diane Tin (786343)
Janet Pope (3464090)

August 2016

Comparison of mean change in outcome measurement scores between early period (0–6 weeks) and late pe...

Clinical pharmacogenetic model to predict response of MTX monotherapy in patients with established rheumatoid arthritis after DMARD failure.

Fransen, J.
Kooloos, W.M.
Wessels, J.A.M.
Huizinga, T.W.J.
Guchelaar (LUMC), H.J.
Riel, P.L.C.M. van
Barrera, P.

January 2012

Contains fulltext : 110572.pdf (publisher's version ) (Closed access)Background: T...

Additional file 1: of 1,25(OH)2D3 and dexamethasone additively suppress synovial fibroblast activation by CCR6+ T helper memory cells and enhance the effect of tumor necrosis factor alpha blockade

Wendy Dankers (5776064)
Claudia GonzĂĄlez-Leal (5776082)
Nadine Davelaar (5776070)
Patrick Asmawidjaja (5776073)
Adriana Mus (5776076)
Johanna Hazes (3502799)
Edgar Colin (5776079)
Erik Lubberts (26108)

September 2018

Table S1. Characteristics of patients used in this study. Figure S1. 1,25(OH)2D3 and DEX minimally a...

SUMMARY

August 2016

Methotrexate (MTX) levels were studied following intravenous MTX in both serum and synovial fluid (S...

Additional file 2: of Methotrexate upregulates circadian transcriptional factors PAR bZIP to induce apoptosis on rheumatoid arthritis synovial fibroblasts

Kohjin Suzuki (4996409)
Kohsuke Yoshida (4996400)
Takeshi Ueha (119906)
Kenta Kaneshiro (4996394)
Ayako Nakai (4996385)
Naonori Hashimoto (4996415)
Koto Uchida (4996403)
Teppei Hashimoto (4996412)
Yoshiko Kawasaki (4996406)
Nao Shibanuma (4996388)
Natsuko Nakagawa (4996391)
Yoshitada Sakai (119945)
Akira Hashiramoto (4996397)

March 2018

Detailed information of patients with RA enrolled in this study. Joint samples obtained from 10 diff...

Additional file 5: of Methotrexate upregulates circadian transcriptional factors PAR bZIP to induce apoptosis on rheumatoid arthritis synovial fibroblasts

Kohjin Suzuki (4996409)
Kohsuke Yoshida (4996400)
Takeshi Ueha (119906)
Kenta Kaneshiro (4996394)
Ayako Nakai (4996385)
Naonori Hashimoto (4996415)
Koto Uchida (4996403)
Teppei Hashimoto (4996412)
Yoshiko Kawasaki (4996406)
Nao Shibanuma (4996388)
Natsuko Nakagawa (4996391)
Yoshitada Sakai (119945)
Akira Hashiramoto (4996397)

March 2018

The mRNA expression of circadian clock genes over time. mRNA expression of circadian clock genes mea...

Additional file 3: of Methotrexate upregulates circadian transcriptional factors PAR bZIP to induce apoptosis on rheumatoid arthritis synovial fibroblasts

Kohjin Suzuki (4996409)
Kohsuke Yoshida (4996400)
Takeshi Ueha (119906)
Kenta Kaneshiro (4996394)
Ayako Nakai (4996385)
Naonori Hashimoto (4996415)
Koto Uchida (4996403)
Teppei Hashimoto (4996412)
Yoshiko Kawasaki (4996406)
Nao Shibanuma (4996388)
Natsuko Nakagawa (4996391)
Yoshitada Sakai (119945)
Akira Hashiramoto (4996397)

March 2018

Plasmid constructs of Per2/Bik promoter. D-box(+), plasmid constructs containing D-box. D-box(−), pl...

Methotrexate upregulates circadian transcriptional factors PAR bZIP to induce apoptosis on rheumatoid arthritis synovial fibroblasts

Kohjin Suzuki
Kohsuke Yoshida
Takeshi Ueha
Kenta Kaneshiro
Ayako Nakai
Naonori Hashimoto
Koto Uchida
Teppei Hashimoto
Yoshiko Kawasaki
Nao Shibanuma
Natsuko Nakagawa
Yoshitada Sakai
Akira Hashiramoto

March 2018

Abstract Background Effects of methotrexate (MTX) on the proliferation of rheumatoid arthritis (RA) ...

Additional file 1: of Autophagy induction contributes to the resistance to methotrexate treatment in rheumatoid arthritis fibroblast-like synovial cells through high mobility group box chromosomal protein 1

Ke Xu (134879)
Yong-song Cai (3529418)
She-Min Lu (3529421)
Xiao-li Li (3529424)
Lin Liu (74495)
Zhong Li (324520)
Hui Liu (33624)
Peng Xu (17962)

December 2015

The expression of P62 in RA-FLS and OA-FLS treated with 0.1ÎźM MTX for the indicated times (TIF 698 ...

Additional file 1: Figure S1. of MMP-3 as a predictor for structural remission in RA patients treated with MTX monotherapy

Kazuko Shiozawa (3555578)
Takashi Yamane (727284)
Miki Murata (3041562)
Ryosuke Yoshihara (3555581)
Ken Tsumiyama (255552)
Shigeaki Imura (3555575)
Shunichi Shiozawa (255561)

February 2016

Annual changes in disease activity score in 28 joints-erythrocyte sedimentation rate (DAS28-ESR) and...

Additional file 1: of Recapitulation of methotrexate hepatotoxicity with induced pluripotent stem cell-derived hepatocytes from patients with rheumatoid arthritis

Juryun Kim (3428045)
Yena Kim (1713244)
Jinhyeok Choi (6164660)
Hyerin Jung (3428042)
Kijun Lee (4888660)
Jaewoo Kang (239124)
Narae Park (4635103)
Yeri Rim (3428039)
Yoojun Nam (3428033)
Ji Ju (3428051)

December 2018

Immunochemisty and AP staining of iPSCs. a, b Immunocytochemistry of HC- and RA-iPSCs. HC: healthy c...

Additional file 2: of Recapitulation of methotrexate hepatotoxicity with induced pluripotent stem cell-derived hepatocytes from patients with rheumatoid arthritis

Juryun Kim (3428045)
Yena Kim (1713244)
Jinhyeok Choi (6164660)
Hyerin Jung (3428042)
Kijun Lee (4888660)
Jaewoo Kang (239124)
Narae Park (4635103)
Yeri Rim (3428039)
Yoojun Nam (3428033)
Ji Ju (3428051)

December 2018

Generation of iPSC-derived hepatocyte-like cells. a, b Morphology and immunocytochemistry images of ...

Drug survival, efficacy and toxicity of monotherapy with a fully human anti-tumour necrosis factor-alpha antibody compared with methotrexate in long-standing rheumatoid arthritis.

Barrera Rico, P.
Maas, A. van der
Ede, A.E. van
Kiemeney, L.A.L.M.
Laan, R.F.J.M.
Putte, L.B.A. van de
Riel, P.L.C.M. van

January 2002

Contains fulltext : 187532.pdf (publisher's version ) (Closed access)OBJECTIVES: T...

Homocysteine and folate status in methotrexate-treated patients with rheumatoid arthritis.

Ede, A.E. van
Laan, R.F.J.M.
Blom, H.J.
Boers, G.H.J.
Haagsma, C.J.
Thomas, C.M.G.
Boo, T.M. de
Putte, L.B.A. van de

January 2002

Contains fulltext : 142827.pdf (publisher's version ) (Closed access)OBJECTIVE: To...

The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules

Johnston, Andrew
Gudjonsson, Johann Eli
Sigmundsdottir, Hekla
Ludviksson, Bjorn Runar
Valdimarsson, Helgi

January 2005

To access publisher full text version of this article. Please click on the hyperlink in Additional L...

Additional file 1: of The rapid kinetics of optimal treatment with subcutaneous methotrexate in early inflammatory arthritis: an observational study

Anna O’Connor (3117774)
Carter Thorne (3508292)
Hyeon Kang (3508295)
Diane Tin (786343)
Janet Pope (3464090)

August 2016

Comparison of mean change in outcome measurement scores between early period (0–6 weeks) and late pe...

Clinical pharmacogenetic model to predict response of MTX monotherapy in patients with established rheumatoid arthritis after DMARD failure.

Fransen, J.
Kooloos, W.M.
Wessels, J.A.M.
Huizinga, T.W.J.
Guchelaar (LUMC), H.J.
Riel, P.L.C.M. van
Barrera, P.

January 2012

Contains fulltext : 110572.pdf (publisher's version ) (Closed access)Background: T...

Additional file 1: of 1,25(OH)2D3 and dexamethasone additively suppress synovial fibroblast activation by CCR6+ T helper memory cells and enhance the effect of tumor necrosis factor alpha blockade

Wendy Dankers (5776064)
Claudia GonzĂĄlez-Leal (5776082)
Nadine Davelaar (5776070)
Patrick Asmawidjaja (5776073)
Adriana Mus (5776076)
Johanna Hazes (3502799)
Edgar Colin (5776079)
Erik Lubberts (26108)

September 2018

Table S1. Characteristics of patients used in this study. Figure S1. 1,25(OH)2D3 and DEX minimally a...

SUMMARY

August 2016

Methotrexate (MTX) levels were studied following intravenous MTX in both serum and synovial fluid (S...

Additional file 4: of Methotrexate upregulates circadian transcriptional factors PAR bZIP to induce apoptosis on rheumatoid arthritis synovial fibroblasts

Abstract

Extracted data

Additional file 4: of Methotrexate upregulates circadian transcriptional factors PAR bZIP to induce apoptosis on rheumatoid arthritis synovial fibroblasts

Abstract

Extracted data

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