Two key cathepsins, TgCPB and TgCPL, are targeted by the vinyl sulfone inhibitor K11777 in <i>in vitro</i> and <i>in vivo</i> models of toxoplasmosis - Fig 3

<p>(A) A single dose of K11777 reduces parasite load in the brain of chicken embryos. K11777 treated chicken embryos (N = 10) (final blood concentration 20 μM) showed a 3-log reduction in parasite burden in brain tissue as measured by quantitative PCR compared to chicken embryos injected with parasites in media alone (N = 10) (Control). Error bars reflect SEM. (B) A single dose of K11777 reduces parasite load in the liver of chick embryos. K11777 treated chicken embryos (final blood concentration 20 μM) showed a 4-log reduction in parasite burden in liver tissue as measured by quantitative PCR compared to chicken embryos injected with parasites in media alone (Control). Error bars reflect SEM.