SH-4-54 decreased STAT3 migration of GBM43 but not of GBM10 in a 3D model of GBM microenvironment.

<p>GBM43 migration distance decreased with SH-4-54 and STAT3 siRNA knockdown treatments (KD-STAT3) while GBM10 migration was not reduced by the inhibitor SH-4-54 or by STAT3 siRNA treatment. Data represents a population of 250–2500 individual cells from 2 replicates. Comparison between groups was done by Kruskal-Wallis test. * Represents statistical significant difference at α = 0.05. Western blots correspond to cells recovered after 48 h of transfection with STAT3 siRNA or control siRNA A.