Initial adult mosquito population sizes have no impact on two performance indicators for the killer-rescue gene drive system.

<p>Panels (a) and (b) show the impacts of early- and late-acting fitness/lethal effects, respectively. The lines represent a general pattern for a given indicator. The top row of plots show the maximum degree of population suppression given by a killer-rescue system whilst the bottom row of plots show the time-taken for the system to reach this level. We find no difference between examples for different values of <i>α</i>. As such, lines are results from a set of numerical simulations spanning the full range of relative fitness parameters (i.e. 0 ≤ <i>ϵ</i>_{<i>A</i>,<i>B</i>} ≤ 1) for a randomly selected value of <i>α</i>.