Docked conformations of indanocine with αβ-tubulin isotypes.

<p>The color for α-tubulin is blue in all αβ-tubulin heterodimers while color of different β-tubulin isotypes is different in all αβ-tubulin heterodimers. The color code for β-tubulin is yellow for tubulin 1SA0, red for isotype βI, light brown for isotype βIIa, violet for isotype βIII, chocolate for isotype βIVa, orange for isotype βIVb, grey for isotype βV and light_green for isotype βVI. Here, indanocine and GTP is shown in stick model and the color code for indanocine and GTP is same as shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0194934#pone.0194934.g001" target="_blank">Fig 1</a>.(A) tubulin 1SA0-indanocine complex (B) αβI tubulin isotype-indanocine complex. (C) αβIIa tubulin isotype-indanocine complex (D) αβIII tubulin isotype-indanocine complex (E) αβIVa tubulin isotype-indanocine complex (F) αβIVb tubulin isotype-indanocine complex (G) αβV tubulin isotype-indanocine complex. (H) αβVI tubulin isotype-indanocine complex. Indanocine prefers the αβ-tubulin interface binding pocket in all human αβ-tubulin isotypes.