Total and proliferating cell densities in real gliomas.

<p>The graphs in (a) compare the mean total cell density (left) and the mean MIB-1 positive cell density (the MIB-1 positive cells are the cells that have entered the cell cycle, i.e. the proliferating cells) (right), inside (red bars) and outside (blue) real gliomas. The data come from 9 different patients, 22 samples inside the tumor (i.e. inside the signal abnormality on T2 MRI scans) and 16 samples ouside. In (b) left, a histological sample of a low-grade glioma, with a hematoxylin-eosin staining, displays a quasi-normal cell density. In (b), right, the same sample stained with the proliferation staining MIB-1, reveals a limited increase in the proliferating cell density compared to normal tissue. The detailed data have been published in [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005977#pcbi.1005977.ref011" target="_blank">11</a>].