Genetic evidence for involvement of an apoptotic cell death program underlying DA neuron degeneration in <i>swip-10</i> animals.

<p>(A) Genetic disruption of the apoptotic cell death pathway, via loss of <i>ced-3</i> or <i>ced-4</i> or gain of function mutation to <i>ced-9</i> significantly reduces <i>swip-10</i> mutant CEP DA neuron degeneration. (B) Genetic disruption of genes involved in cell-corpse engulfment had no effect on the observed DA neuron degeneration of <i>swip-10</i> mutants. Analyzed by one-way ANOVA with Sidak’s post-tests (A and B), **** indicates <i>P</i><0.0001, and ns = non-significant (<i>P</i>>.05), error bars represent ± SEM, with n = 105–150 animals per strain.