Disruption of Glu signaling attenuates the DA neuron degeneration of <i>swip-10</i> mutants.

<p>(A) Loss of the vesicular Glu transporter, <i>vglu-3</i>, suppresses <i>swip-10</i> DA neuron degeneration, whereas loss of <i>eat-4</i> or <i>vglu-2</i> does not significantly alter the levels of <i>swip-10</i> neurodegeneration. (B) Disrupting Glu clearance by loss of individual Glu transporters is not sufficient to induced DA neurodegeneration. (C) Loss of the amino acid transporter, <i>aat-1</i>, but not <i>aat-2</i>, <i>aat-3</i>, <i>aat-5</i>, <i>aat-6</i>, <i>aat-7 or aat-9</i>, significantly attenuates the DA neuron degeneration of <i>swip-10</i> mutants. Data were analyzed by a one-way ANOVA with Sidak’s post-tests, with * and *** indicating <i>P</i><0.05 and <0.001 respectively, error bars represent ± SEM, with n = 105–150 animals per strain.