<i>Ppip5k2</i>^<i>K</i><i>^</i>^<i>/K</i><i>^</i> mice exhibit late onset high-frequency decline in ABR wave I amplitudes.

<p>Average pure tone-evoked ABR wave I amplitudes and latencies in <i>Ppip5k2</i>^<i>+/+</i>, <i>Ppip5k2</i>^<i>+/K</i><i>^</i>, and <i>Ppip5k2</i>^<i>K</i><i>^</i>^<i>/K</i><i>^</i> at different time points (P60, P90, P120, P150) were assessed (n = 7; mean ± SEM). Significantly reduced wave I amplitudes at 24KHz were detected at P120 in <i>Ppip5k2</i>^<i>K</i><i>^</i>^<i>/K</i><i>^</i> mice (*p < 0.01). At P150 both the homozygous and heterozygous <i>Ppip5k2</i>^<i>K</i><i>^</i> mice had significantly reduced wave I amplitudes at 24KHz mice (**p < 0.05). These results suggest impaired late onset auditory neuronal function in PPIP5K2 mutant mice.