The bistable switch in the core network depending on (<i>a</i><sub><i>3</i></sub>, <i>a</i><sub><i>7</i></sub>) parameters and at <i>h = 6</i>.
- Ilya R. Akberdin (538948)
- Nadezda A. Omelyanchuk (5040200)
- Stanislav I. Fadeev (5040197)
- Natalya E. Leskova (5040194)
- Evgeniya A. Oschepkova (5040203)
- Fedor V. Kazantsev (5040206)
- Yury G. Matushkin (5040191)
- Dmitry A. Afonnikov (727755)
- Nikolay A. Kolchanov (5691)
Publication date
March 2018
DOIAbstract
<p>Highlighted region is the range of parameter values, having which the system has switch-like behavior. Furthermore, the analysis indicated that a straight line <i>a</i><sub><i>3</i></sub> = <i>a</i><sub><i>7</i></sub> divides the plane (<i>a</i><sub><i>3</i></sub>, <i>a</i><sub><i>7</i></sub>) it into two areas. When <i>a</i><sub><i>3</i></sub> < <i>a</i><sub><i>7</i></sub>, the cell has differentiated state at all values <i>A</i> ≥ <i>0</i>. When <i>a</i><sub><i>3</i></sub> > <i>a</i><sub><i>7</i></sub>, there will be some <i>A</i><sub><i>0</i></sub>, that upon <i>A</i> > <i>A</i><sub><i>0</i></sub> the cell is pluripotent, while at <i>A</i> < <i>A</i><sub><i>0</i></sub> the cell will differentiate.</p
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