P210 is important for selection of the -2 and +1 nucleotides at the A3G deamination sites.
- Samantha J. Ziegler (5040659)
- Chang Liu (35901)
- Mark Landau (5040665)
- Olga Buzovetsky (5040662)
- Belete A. Desimmie (1944142)
- Qi Zhao (124612)
- Tomoaki Sasaki (5040668)
- Ryan C. Burdick (704506)
- Vinay K. Pathak (265960)
- Karen S. Anderson (1343331)
- Yong Xiong (313431)
DOIAbstract
<p>A) Relative single-cycle infectivity of VSV-G-psuedotyped HIV-1Δ<i>vif</i> viruses produced in the presence or absence of A3G-WT or A3G-P210R. Mean of two independent experiments done in triplicates are shown relative to the “no A3G” control (set to 100%); error bars, standard deviation. B and C) Effect of A3G-P210R substitution on the relative mutation frequencies at the +1 position nucleotide (b) and the -2 position nucleotide (c) with the preferred C at the -1 position (5’C<u><b>C</b></u>) or the non-preferred T at the -1 (5’T<u><b>C</b></u>) position. B) In the + 1 position nucleotide, mutation frequencies for the preferred sites with a C at -1 position (5’C<u><b>C</b></u>), A3G-WT prefers C<u><b>C</b></u>A or C<u><b>C</b></u>G over ...
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