Mutations in the pantothenate kinase of <i>Plasmodium falciparum</i> confer diverse sensitivity profiles to antiplasmodial pantothenate analogues - Fig 10

<p><b>Percentage parasite proliferation of the different lines in the presence of the pantothenate analogues (a) N5-trz-C1-Pan and (b) <i>N</i>-PE-αMe-PanAm, and inhibition of [¹⁴C]pantothenate phosphorylation in parasite lysates by various pantothenate analogues: (c) PanOH, (d) CJ-15,801, (e) N5-trz-C1-Pan and (f) <i>N</i>-PE-αMe-PanAm.</b> Symbols represent Parent (white circles), PanOH-A (black triangles), PanOH-B (black squares) and CJ-A (black diamonds) parasite lines. The Y-axes of c−f indicate the percentage of total pantothenate phosphorylation. Values are averaged from ≥ 3 independent experiments, each carried out in triplicate for the parasite proliferation assays and duplicate for the phosphorylation assays. Error bars represent SEM and are not visible if smaller than the symbols.