Outer surface potential modulates excitability in CA1 neurons after changes in extracellular pH.

<p>Representative responses of CA1 neurons from hippocampus of WT (<b>A</b>) and RTT animals (<b>B</b>) to current injections. Note the clear differences between responses recorded in the acidic (suppression of activity) and alkaline ACSF (activation) from that in the control. <b>C</b> and <b>D</b> Input-output relationships of CA1 neurons from each genotype. The number of APs fired vs. intensities of current injection.