Impact of the obstructive sleep apnea syndrome on left ventricular remodeling among people with different body weight

The aim of the study: to estimate the structural changes of LV among people with unrecognized OSAS and different body weight. Materials and methods. The study involved 74 patients with OSAS. All subjects were divided into two groups: with obesity and with normal body weight. Patients with hypertension, diabetes mellitus or any other known cardiac and renal diseases, with central sleep apnea were excluded from the study. 20 healthy people were included in the control group. Each patient underwent a clinical evaluation, 24-hour ambulatory blood pressure monitoring, cardiorespiratory monitoring, transthoracic echocardiography. Pearson correlation analysis, univariate and multivariate regression analysis were performed. Results: Ten patients from all enrolled subjects were diagnosed with LV hypertrophy. Estimated LVM and LVMI increased in group I in comparison with the group II and control group. Significant differences between group II and control group concerning LVMI and LVM weren`t admitted. A significant difference for PWTd and IVSd were observed in group I and group II, compare to control group. The LVMI was positive ly correlated with DI even after adjustment for the BMI. The LVM correlate with mean SaO2 and the lowest SaO2. The univariate regression analysis showed that the lowest SaO2, DI, AHI were associated with LVMI. Conclusions. OSAS and obesity are associated with high LVM, LVMI and prevalence of concentric LV remodeling. The LVMI was increased parallel to an increasing in the OSAS severity in patients with obesity. There were admitted statistically significant differences for PWTd and IVSd among patients with OSAS without obesity and healthy people. Concerning LVMI and LVM, no statistically significant differences were admitted. The lowest SaO2 and DI were associated with changes of LVMI, LVM, PWTd and IVSd according to the results of regression analysis