Long-term Prognosis and Recurrence of Primary Sclerosing Cholangitis After Liver Transplantation: A Single-Center Experience
- Yoshihide Ueda, MD, PhD
- Toshimi Kaido, MD, PhD
- Hideaki Okajima, MD, PhD
- Koichiro Hata, MD, PhD
- Takayuki Anazawa, MD, PhD
- Atsushi Yoshizawa, MD, PhD
- Shintaro Yagi, MD, PhD
- Kojiro Taura, MD, PhD
- Toshihiko Masui, MD, PhD
- Noriyo Yamashiki, MD, PhD
- Hironori Haga, MD, PhD
- Miki Nagao, MD, PhD
- Hiroyuki Marusawa, MD, PhD
- Hiroshi Seno, MD, PhD
- Shinji Uemoto, MD, PhD
DOIAbstract
Background. Primary sclerosing cholangitis (PSC) is a progressive cholestatic liver disease, with liver transplantation being the sole life-saving treatment for end-stage PSC-related liver disease. However, recurrence of PSC after liver transplantation is a common complication, with the risk factors for recurrence being controversial. Methods. We conducted a retrospective chart review of 45 patients who had undergone liver transplantation for PSC at our institute. The risk factors for PSC recurrence and graft failure after liver transplantation were analyzed. Results. The graft survival rates were 55.4% at 5 years and 32.8% at 10 years after liver transplantation for PSC. PSC recurrence was diagnosed in 16 (40%) of 40 patients, at a median ...