Effects of sevoflurane + propofol + remifentanil intravenous inhalational anesthesia on brain injury and oxidative stress response in patients with cerebral hemorrhage after craniotomy

Objective: To study the effects of sevoflurane + propofol + remifentanil intravenous inhalational anesthesia on brain injury and oxidative stress response in patients with cerebral hemorrhage after craniotomy. Methods: Patients with cerebral hemorrhage who received craniotomy in Chongzhou People’s Hospital in Sichuan Province between July 2014 and February 2017 were selected and randomly divided into two groups, Sev group received sevoflurane + propofol + remifentanil anesthesia, and control group received propofol + remifentanil anesthesia. The brain injury indexes and oxidative stress indexes in serum and peripheral blood were measured 12 h and 24 h after surgery. Results: 12 h and 24 h after surgery, serum Hep, NSE, S100β, Asp, HA, MMP9, OPN, ICAM-1, Cor and MDA levels as well as peripheral blood Nrf-2 and TRX mRNA expression of Sev group were greatly lower than those of control group whereas serum SOD and T-AOC levels were greatly higher than those of control group. Conclusion: sevoflurane + propofol + remifentanil intravenous inhalational anesthesia can reduce the br